Determining the best duration for patients with ARDS in the prone position
By Assessing the Continuous Respiratory Physiological Changes Through Prone Position, Determine the Optimal Duration for Prone Position
This study is testing how long patients with Acute Respiratory Distress Syndrome should stay in a face-down position to see if it helps their breathing and reduces inflammation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 1 site (Taipei) |
| Trial ID | NCT06827184 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the continuous respiratory physiological changes in patients with Acute Respiratory Distress Syndrome (ARDS) when placed in the prone position. By utilizing Electrical Impedance Tomography (EIT), the study will monitor alterations in regional ventilation and inflammation biomarkers before and after adopting the prone position. The goal is to identify the optimal duration for prone position therapy, which includes determining the necessary hours and days for effective treatment. Data will be collected from consenting patients to analyze these changes comprehensively.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old diagnosed with Acute Respiratory Distress Syndrome and requiring specific mechanical ventilation settings.
Not a fit: Patients with certain exclusions, such as those with implantable electronic devices or unstable medical conditions, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could optimize prone position therapy for ARDS patients, potentially improving their respiratory function and outcomes.
How similar studies have performed: While the use of prone positioning in ARDS has been studied, this specific approach utilizing EIT to determine optimal duration is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Acute respiratory distress syndrome 2. Age \> 18 3. Serial arterial blood gas data：PaO2/FiO2 \<150. The mechanical ventilator setting：FiO2\>0.6, PEEP\>5 cmH2O Exclusion Criteria: 1. Implantable electronic devices (e.g., pacemakers) 2. Body mass index \> 30 3. Major thoracic and abdominal surgery 4. Patients with unstable spine and pelvis conditions 5. Pregnant women in the second and third trimesters 6. Patients with head trauma, elevated intracranial pressure, or elevated intraocular pressure 7. Hemodynamically unstable patients unsuitable for prone ventilation therapy 8. Patients with active seizures
Where this trial is running
Taipei
- National Taiwan University Hospital — Taipei, Taiwan (Recruiting)
Study contacts
- Principal investigator: Ting-Yu Liao, MD — National Taiwan University Hospital
- Study coordinator: Ting-Yu Liao, MD
- Email: tingyuliao@ntuh.gov.tw
- Phone: +886 2 23123456
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.