Determining the best duration for patients with ARDS in the prone position
Official title: By Assessing the Continuous Respiratory Physiological Changes Through Prone Position, Determine the Optimal Duration for Prone Position
Run by National Taiwan University Hospital · NCT06827184 · Data updated 2026-11-12
This study is testing how long patients with Acute Respiratory Distress Syndrome should stay in a face-down position to see if it helps their breathing and reduces inflammation.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 1 site (Taipei) |
| Status | Recruiting |
| Started | September 20, 2024 |
| Main results expected | August 31, 2030 |
| Study ends | December 31, 2030 |
| Registry record updated | February 19, 2025 |
| Trial ID | NCT06827184 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old diagnosed with Acute Respiratory Distress Syndrome and requiring specific mechanical ventilation settings.
✕Probably not a fit
Patients with certain exclusions, such as those with implantable electronic devices or unstable medical conditions, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the continuous respiratory physiological changes in patients with Acute Respiratory Distress Syndrome (ARDS) when placed in the prone position. By utilizing Electrical Impedance Tomography (EIT), the study will monitor alterations in regional ventilation and inflammation biomarkers before and after adopting the prone position. The goal is to identify the optimal duration for prone position therapy, which includes determining the necessary hours and days for effective treatment. Data will be collected from consenting patients to analyze these changes comprehensively.
Why it matters
Potential benefit: If successful, this study could optimize prone position therapy for ARDS patients, potentially improving their respiratory function and outcomes.
How similar studies have gone: While the use of prone positioning in ARDS has been studied, this specific approach utilizing EIT to determine optimal duration is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Acute respiratory distress syndrome 2. Age \> 18 3. Serial arterial blood gas data：PaO2/FiO2 \<150. The mechanical ventilator setting：FiO2\>0.6, PEEP\>5 cmH2O Exclusion Criteria: 1. Implantable electronic devices (e.g., pacemakers) 2. Body mass index \> 30 3. Major thoracic and abdominal surgery 4. Patients with unstable spine and pelvis conditions 5. Pregnant women in the second and third trimesters 6. Patients with head trauma, elevated intracranial pressure, or elevated intraocular pressure 7. Hemodynamically unstable patients unsuitable for prone ventilation therapy 8. Patients with active seizures
Where it's running
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National Taiwan University Hospital
Taipei, Taiwan Recruiting
Study contacts
- Principal investigator: Ting-Yu Liao, MD — National Taiwan University Hospital
- Study coordinator: Ting-Yu Liao, MD
- Email: tingyuliao@ntuh.gov.tw
- Phone: +886 2 23123456
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.