PEEP Titration Guided by Electrical Impedance Tomography in Laparoscopic Surgery
Official title: Personalized PEEP Titration Guided by Electrical Impedance Tomography in Patients Undergoing Laparoscopic Surgery: A Randomized Controlled Trial - The PEaRL Study
Run by ASST Fatebenefratelli Sacco · NCT07289113 · Data updated 2026-11-12
This study tests whether using Electrical Impedance Tomography to guide personalized PEEP during laparoscopic surgery can improve breathing outcomes for patients undergoing abdominal procedures.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 52 (estimated) |
| Sponsor | ASST Fatebenefratelli Sacco Academic / other |
| Locations | 1 site (Milan, Lombardy) |
| Status | Recruiting |
| Started | January 12, 2026 |
| Main results expected | October 2026 |
| Study ends | November 2026 |
| Registry record updated | June 4, 2026 |
| Trial ID | NCT07289113 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults scheduled for laparoscopic abdominal surgery without COPD, acute respiratory failure, hemodynamic instability, pregnancy, or contraindications to the EIT device who provide informed consent.
✕Probably not a fit
Patients with certain lung conditions or instability may not benefit from the tailored PEEP approach and could potentially be exposed to minimal added procedural steps.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study evaluates a personalized PEEP titration approach during laparoscopic abdominal surgery. Using Electrical Impedance Tomography with the PulmoVista 500, clinicians identify the optimal PEEP to balance alveolar recruitment and overdistension. The goal is to improve intraoperative lung mechanics and postoperative gas exchange while reducing respiratory complications. The trial is conducted at a Milan anesthesia and intensive care department under the lead sponsor ASST Fatebenefratelli Sacco. Eligible participants are adults scheduled for laparoscopic abdominal surgery who provide informed consent and do not have exclusion conditions such as COPD or hemodynamic instability.
Why it matters
Potential benefit: If successful, patients could experience better intraoperative oxygenation and lung mechanics, potentially reducing postoperative respiratory complications.
How similar studies have gone: Previous work on personalized PEEP and imaging-guided ventilation has shown promise, but this exact EIT-guided PEEP approach in laparoscopic surgery is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * scheduled for laparoscopic abdominal surgery * informed consent signed Exclusion Criteria: * COPD * Acute respiratory failure * Hemodynamic instability * Pregnancy * Contraindications for EIT device
Where it's running
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Department of Anesthesia and Intensive Care Medicine
Milan, Lombardy, Italy Recruiting
Study contacts
- Principal investigator: Tommaso Fossali, MD — ASST Fatebenefratelli Sacco
- Study coordinator: Tommaso Fossali
- Email: fossali.tommaso@asst-fbf-sacco.it
- Phone: +393282194697
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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EIT-guided PEEP personalization for trauma- and postoperative ARDS
This trial tests whether using bedside electrical impedance tomography (EIT) to set PEEP helps adults with moderate to severe ARDS after trauma or major surgery breathe and oxygenate better.
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Using Electrical Impedance Tomography to Improve Breathing During Abdominal Laparoscopic Surgery
This study tests if using a special breathing technique with electrical sensors can help patients breathe better during abdominal surgery compared to standard methods.
-
Determining the best duration for patients with ARDS in the prone position
This study is testing how long patients with Acute Respiratory Distress Syndrome should stay in a face-down position to see if it helps their breathing and reduces inflammation.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.