Effects of variable resistance training on neural adaptations
Official title: Neural Adaptations to Metronome-Paced Strength Training: Insights From Neuroscience and Human Movement Variability
Run by Egas Moniz - Cooperativa de Ensino Superior, CRL · NCT06532786 · Data updated 2026-11-12
This study is testing if adding different timing styles to strength training can improve muscle control and brain function in healthy adults aged 18 to 40.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 40 Years |
| Sex | Men only |
| Enrollment | 60 (estimated) |
| Sponsor | Egas Moniz - Cooperativa de Ensino Superior, CRL Academic / other |
| Locations | 1 site (Almada, Monte de Caparica) |
| Status | Recruiting |
| Started | September 15, 2024 |
| Main results expected | August 30, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | January 16, 2026 |
| Trial ID | NCT06532786 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are healthy adults aged between 18 and 40 years.
✕Probably not a fit
Patients with neurologic conditions, lower limb disabilities, or those unable to provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates how incorporating variability into resistance training methods affects neural adaptations in the corticospinal tract and neuromuscular function. It aims to enhance motor control by using a metronome-paced strength training approach that includes fractal-like variability, which is often absent in traditional resistance training. The study will compare different pacing methods, including fractal paced, isochronous paced, and self-paced training, to assess their impact on muscle function and neural drive. Participants will be healthy adults aged 18 to 40, and the study will utilize techniques such as Transcranial Magnetic Stimulation to measure outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved resistance training methods that enhance motor control and muscle function in healthy individuals.
How similar studies have gone: While the approach of incorporating variability in resistance training is innovative, similar studies have shown promise in enhancing motor control and neuromuscular function.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * aged between 18 and 40 years Exclusion Criteria: * Neurologic conditions; * Lower limb disabilities or disease; * Not able to provide informed consent; * Have an implanted device (e.g. pacemakers) or any metal in the body; * Medication advised against the application of Transcranial Magnetic Stimulation; * History/family history of seizures, brain lesions or head trauma, neurological or psychiatric diseases, epilepsy, migraine
Where it's running
-
Egas Moniz School of Health & Science
Almada, Monte de Caparica, Portugal Recruiting
Study contacts
- Study coordinator: João H Oliveira, MSc
- Email: joao.henriques.oliveira@gmail.com
- Phone: 913266232
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.