Effects of Saccharomyces Boulardii on Gut Barrier Function

Inclusion Criteria:

* Considered as healthy after a comprehensive clinical assessment (detailed medical history and complete physical examination).
* With a body mass index (BMI) comprised between 18 and 35 kg/m\^2 and weight \> 50 kg at Screening.
* Able to comply with study requirements and to provide signed informed consent.
* Has signed the informed consent form before beginning any study procedure.
* Regular defecation (frequency and stool consistency, with at least about three bowel movements a week).
* For women of childbearing potential:

  * A negative urine pregnancy test immediately prior to starting the study treatment;
  * Agreement to comply with approved methods of contraception during the whole study: unless they meet the criteria of post-menopausal; i.e., 12 months of spontaneous amenorrhea, women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, including women whose career, lifestyle, or sexual orientation precludes intercourse with a male partner, should use one or more of the following acceptable methods of contraception that should be maintained throughout the study:
  * Surgical sterilization;
  * Hormonal contraception (implantable, patch, oral, intra-muscular);
  * Intra-uterine device;
  * Double barrier method (diaphragm plus condom);
  * At the discretion of the investigator, total abstinence is acceptable in cases where age, career, lifestyle, or sexual orientation of the patient ensures compliance.

Exclusion Criteria:

* History of hypersensitivity to the study treatments (active substance or excipients), brewer's or baker's yeast.
* Contraindication and special warning to the study treatments according to the Summary of Product Characteristics (SmPCs).
* History of chronic constipation with passage of fewer than 3 spontaneous bowel movements per week on average.
* History of chronic or recurrent diarrhea with spontaneous unformed bowel movements equivalent to or more often than 3 times daily.
* Prior gastrointestinal surgery (apart from appendectomy or cholecystectomy performed at least more than one year ago).
* History of Clostridium difficile infection.
* Active gastrointestinal disease.
* Known chronic or recurrent systemic disorder (including diabetes and hypertension) that may interfere with the study treatment evaluation.
* Associated immune deficiency.
* Severe hepatic or renal impairment.
* Clinically relevant abnormalities in results of laboratory tests as per Investigator's judgement.
* Patients with a central venous catheter.
* Oral or systemic antibacterial therapy during the 3 months prior to study enrollment.
* NSAIDs and proton pump inhibitor treatment longer than 1 week, within 3 months prior to study enrollment.
* Steroids within 6 weeks prior to study enrollment.
* Use of medications affecting gastrointestinal transit or permeability within 7 days prior to the testing.
* Use of artificial sweeteners, lactulose, mannitol within 2 days prior to the testing and during the 24 h testing period.
* New prescription medications during the 2 weeks prior to study enrollment.
* Use of probiotics or drugs that alters gut microbiota or function, during 4 weeks prior to study enrollment.
* Intake of antifungals within 14 days prior to study enrollment.
* Substantial changes in eating habits within 30 days prior to receiving the first dose of IMP product, as assessed by the Investigator.
* Current smoker.
* History or presence of drug or alcohol abuse.
* Inability to abstain from intensive muscular effort the day before the intestinal permeability test.
* Breast-feeding woman.
* Patients enrolled in another clinical trial within the past 30 days.
* Patients not able to fill in the study questionnaires.
* Any condition or personal circumstance that, in the opinion of the investigator, renders the subject unlikely or unable to comply with the full study protocol.