Effects of different anesthetics on cancer prognosis
To Compare the Effects of Intraoperative Use of Intravenous Anesthetics Propofol and Inhaled Anesthetics Sevoflurane on the Prognosis of Patients Undergoing Surgery for Primary Brain, Liver, Lung, and Ovarian Cancer Tumors and the Investigation of Its Mechanism of Action
This study tests whether using different types of anesthesia during cancer surgery affects recovery and survival for patients with various cancers.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 1316 (estimated) |
| Ages | 20 Years to 80 Years |
| Sex | All |
| Sponsor | Kaohsiung Medical University Chung-Ho Memorial Hospital Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Kaohsiung City) |
| Trial ID | NCT05926336 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates how the use of two different anesthetics, propofol and sevoflurane, affects the prognosis of patients undergoing elective surgery for various types of cancer, including lung, brain, liver, and ovarian cancers. Participants are randomly assigned to receive either propofol or sevoflurane during their surgery, with careful monitoring of vital signs and anesthetic dosages. The study aims to evaluate postoperative complications, overall survival rates, and the impact on patients' functional status over time.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 80 with ASA class I-III who are scheduled for elective surgery for brain, liver, lung, or ovarian cancer.
Not a fit: Patients with severe mental disorders, poor liver function, or those undergoing emergency surgeries are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved survival outcomes for cancer patients by identifying the optimal anesthetic approach.
How similar studies have performed: Other studies have shown varying results regarding the impact of anesthetic choice on cancer outcomes, making this approach both relevant and potentially novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * eighteen to eighty-year-old * ASA class I-III patients * Elective surgery for brain, liver, lungs, ovarian cancer under general anesthesia Exclusion Criteria: * Severe mental disorder, poor liver function, pregnant or lactating women, morbidly obese, allergy to any of the drugs used in this study, recurrent tumor or repeat surgery, biopsy cases, incomplete outcome-data, palliative treatment after surgery, simultaneous treatment of other malignancies, emergency surgery, presence of other malignant tumors, combined propofol and inhalation anesthesia or other anesthetics, such as ketamine or dexmedetomidine, diagnosed as benign brain, liver, lungs, ovarian cancer、cell carcinoma or other metastatic.
Where this trial is running
Kaohsiung City
- Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan (Recruiting)
Study contacts
- Principal investigator: Zhi-Fu Wu — Kaohsiung Medical University
- Study coordinator: Zhi-Fu Wu, MD
- Email: aneswu@gmail.com
- Phone: 07-3121101
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.