Effects of bariatric surgery on the absorption of amlodipine
Bariatric Surgery and Pharmacokinetics Amlodipine: BAR-MEDS Amlodipine
This study is testing how bariatric surgery affects the way the body absorbs amlodipine, a medication for high blood pressure, in patients getting ready for these surgeries.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 12 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Norwegian University of Science and Technology Academic / other |
| Locations | 1 site (Trondheim) |
| Trial ID | NCT02904291 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how bariatric surgery, specifically gastric bypass and sleeve gastrectomy, affects the pharmacokinetics of amlodipine, a medication used to treat high blood pressure. It aims to understand changes in gastric pH, gastric emptying time, and gastrointestinal transit-time that may influence the biological availability of the drug. The study will involve patients preparing for these surgical procedures in Central Norway, focusing on how their surgery impacts medication absorption.
Who should consider this trial
Good fit: Ideal candidates are Norwegian citizens preparing to undergo gastric bypass or sleeve gastrectomy.
Not a fit: Patients who have previously undergone resections in the gastrointestinal tract may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved medication management for patients undergoing bariatric surgery.
How similar studies have performed: While the specific pharmacokinetic effects of bariatric surgery on amlodipine are not well-studied, similar research has shown that surgical interventions can significantly alter drug absorption.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway * Being a Norwegian citizen Exclusion Criteria: * Having previously undergone resections in the GI-tract
Where this trial is running
Trondheim
- St. Olavs University Hospital — Trondheim, Norway (Recruiting)
Study contacts
- Principal investigator: Magnus Strømmen, MSc — St. Olavs Hospital
- Study coordinator: Magnus Strømmen, MSc
- Email: magnus.strommen@stolav.no
- Phone: 0047 72829970
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.