Effect of ketamine on nerve function during spinal surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to investigate how ketamine affects intraoperative motor evoked potentials (MEPs) in adult patients undergoing thoracolumbar spinal fusions. Participants will receive a standard anesthetic along with increasing doses of ketamine, while MEPs will be monitored to evaluate any changes in spinal cord function. The study seeks to enhance understanding of how adjunct anesthetics like ketamine influence neurophysiological monitoring during complex spinal surgeries. This could lead to improved safety protocols and pain management strategies in surgical settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (\>18 years of age) undergoing posterior spinal fusions.

Exclusion Criteria:

* Sensitivity or allergy to ketamine.
* Schizophrenia or other psychotic conditions
* Uncontrolled hypertension with systolic blood pressure greater than 180 mmHg
* Myocardial Infarction
* Large vascular aneurysms
* Patients on ketamine as outpatient therapy.

Where it's running

• University of California, San Francisco
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Marc Buren, MD — University of California, San Francisco
• Study coordinator: Marc Buren, MD
• Email: marc.buren@ucsf.edu
• Phone: 4154768369

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.