Cytokines, Neuroplasticity Modulators, and Biomarkers in Spinal Canal Stenosis with Endoscopic Decompression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial explores the role of inflammatory signals and biomarkers related to neuroplasticity in lumbar spinal canal stenosis and examines changes around the endoscopic decompression procedure. It includes adults with proper MRI-confirmed stenosis who are scheduled for endoscopic decompression and a control group with disc herniation without stenosis. Participants will be evaluated for biomarker profiles in relation to inflammation, adipose tissue signaling, and tissue remodeling. The study aims to better understand the biological mechanisms contributing to LF hypertrophy and stenosis progression. The design incorporates surgical patients and biomarker analyses to correlate pathology with clinical status.

Why it matters

Who can join: the full rules

Inclusion Criteria for the experimental group:

1. Spinal stenosis in the lumbar spine with a referral for surgical treatment using endoscopic spinal decompression.
2. Age: 40-90 years.
3. Current MRI results.
4. Consent to participate in the study.

Inclusion Criteria for the control no spinal stenosis group:

1. Intervertebral disc herniation in the lumbar spine with a referral for surgical treatment using endoscopic discectomy.
2. Age: 18-40 years.
3. Current MRI results.
4. Consent to participate in the study.

Exclusion Criteria:

History of:

* rheumatoid arthritis of the intervertebral joints,
* joint pain located elsewhere if it is more severe than the pain caused by stenosis,
* pathologies and/or medications that may disturb the balance between pro- and anti-inflammatory factors (e.g. inflammatory diseases, rheumatoid arthritis, ankylosing spondylitis, acute infection),
* uncontrolled diabetes, poorly controlled hypertension, clinically significant liver function impairment, acute coronary event, unstable angina pectoris, symptoms of heart failure, pacemaker implantation,
* neurological diseases within the last 6 months,
* previous spine surgery at the lumbar level,
* mechanical injuries to the spine after an accident,
* advanced osteoporosis,
* pregnancy, lactation.

Where it's running

• Ortopedyczno-Rehabilitacyjny Szpital Kliniczny im. Wiktora Degi w Poznaniu
  Poznan, Wielkopolska, Poland Recruiting

Study contacts

• Principal investigator: Marzena Ratajczak, PhD — Poznan University of Physical Education
• Study coordinator: Marzena Ratajczak, PhD
• Email: mratajczak@awf.poznan.pl
• Phone: +48 604773816

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.