Early Neurovascular Decoupling After Revascularization in Acute Ischemic Stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows patients who had successful endovascular thrombectomy for anterior circulation ischemic stroke. It uses multimodal neuromonitoring to characterize early neurovascular decoupling—the disruption between neural activity and blood flow—and how these trajectories relate to long-term functional outcomes. Researchers will build a composite biomarker from multimodal data to see if it can predict 90-day recovery. The study aims to improve prognostic accuracy and inform individualized rehabilitation strategies. Enrollment includes adults 18–85 who reached treatment within 24 hours and achieved successful reperfusion (mTICI 2b/3).

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age between 18 and 85 years
2. Acute ischemic stroke due to occlusion of the anterior circulation large vessel (terminal internal carotid artery, or M1/M2 segment of the middle cerebral artery), confirmed by computed tomography angiography (CTA) or magnetic resonance angiography (MRA).
3. Underwent endovascular thrombectomy with successful reperfusion, defined as a post-procedural modified Thrombolysis in Cerebral Infarction (mTICI) grade of 2b or 3.
4. Time from symptom onset to femoral artery puncture is ≤ 24 hours.
5. Written informed consent is provided by the patient or their legally authorized representative.

Exclusion Criteria:

1. Pre-stroke disability defined as a modified Rankin Scale (mRS) score ≥ 2.
2. Severe impairment of consciousness within 24 hours post-thrombectomy, defined as a Glasgow Coma Scale (GCS) score ≤ 8.
3. Inadequate temporal bone window preventing acquisition of stable blood flow signals by Transcranial Doppler (TCD).
4. Conditions that may significantly compromise electroencephalography (EEG) quality, such as history of significant traumatic brain injury, skull defect, or intracranial metallic devices.
5. Conditions that may invalidate F-wave studies, including peripheral neuropathy, cervical radiculopathy, or primary disease of the target muscles.
6. Concurrent severe organ failure, malignancy, or a life expectancy of less than 3 months.
7. Pregnancy or lactation.

Where it's running

• Department of Neurology, Xijing Hospital, Air force medical university
  Xi'an, Shan'xi, China Recruiting
• Department of Neurology, Xijing Hospital, Air force medical university
  Xi'an, Shan'xi, China Recruiting

Study contacts

• Principal investigator: Lang Jin — Xijing Hospital
• Study coordinator: Lang Jin
• Email: silencelang@163.com
• Phone: +86-29-84773664

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.