Early detection of neuropathologies affecting drivers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The project uses a two-phase, observational design starting with healthy volunteers completing the Vienna Test System (VTS) to establish baseline performance. In the clinical phase, people with diagnosed multiple sclerosis or Parkinson's disease complete a basic neurological exam (including MoCA, 25-Foot Walk, SDMT, and Nine-Hole Peg Test) followed by VTS testing. Patients are staged with EDSS for MS and Hoehn and Yahr for PD to relate disease severity to test results. The goal is to find which easily accessible clinical tests best correlate with VTS outcomes and to develop a practical risk equation and targeted training approaches to support safe driving.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Person after signing informed consent.
* After meeting the valid diagnostic criteria for the given neurological diagnosis.
* Possession of a valid driver's license and proof of active driving.
* Age limit 18 - 85 years.

Exclusion Criteria:

* Proven diagnosis of dementia based on a current psychological examination (MMSE 24 points or less).
* Diagnosis of a disease or condition that, according to Czech Law. No. 277/2004 Coll., on medical fitness to drive motor vehicles, as amended (especially Law No. 204/2025 Coll.), prevents or significantly limits the ability to drive a motor vehicle safely (e.g. dementia, epilepsy, severe disorders of consciousness).
* Age less than 18 years.
* Age more than 85 years.
* In the second cohort (patients with Multiple Sclerosis), proven and treated relapse in the last 6 weeks before inclusion in the study.
* In the MS cohort, current EDSS \> 6.5 points.
* For the PD cohort, the current Hoehn and Yahr scale score is greater than or equal to 4.
* For both cohorts, evidence of parainfectious deterioration as demonstrated by laboratory testing.

Where it's running

• University hospital Olomouc
  Olomouc, Olomouc Region, Czechia Recruiting

Study contacts

• Study coordinator: Dalibor Zimek, M.D.
• Email: Dalibor.Zimek@fnol.cz
• Phone: +420 702 048 036

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.