Early detection of initial caries with fluorescent starch nanoparticles versus salivary biomarkers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study aims to see if fluorescent starch nanoparticles can identify early enamel caries that are not yet cavitated. Participants with at least one suspected initial lesion will undergo testing with the fluorescent nanoparticles and analysis of salivary biomarkers. The study compares the nanoparticle method to saliva-based indicators to determine which approach detects early demineralization more reliably. Conventional methods like visual-tactile exams and bitewing radiographs are acknowledged as limited at this stage. The trial is conducted at Menoufia Dental Hospital under the lead sponsorship of Menoufia University.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- Presence of at least one suspected initial enamel carious lesion.

Exclusion Criteria:

* Cavitated carious lesions
* Previous restorative treatment on the examined tooth
* Antibiotic therapy during the previous month,
* Systemic diseases affecting salivary secretion
* Xerostomia or salivary gland disorders

Where it's running

• Menoufia Dental Hospital
  Shibīn al Kawm, Menoufia, Egypt Recruiting

Study contacts

• Study coordinator: Walaa Mohamed Hassan, M.D
• Email: walaamohammed700@dent.menofia.edu.eg
• Phone: +201098246330

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.