Dynamic SvO2 to predict fluid responsiveness in septic shock

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational study compares dynamic ScvO2 with echocardiography (VTI) and electrical cardiometry to see if changes after a fluid challenge predict fluid responsiveness in septic shock. Measurements are taken at baseline and after fluid bolus, with standardized hemodynamic monitoring and vasopressor management kept constant during the assessment. Echocardiography is performed by an experienced, blinded operator, while noninvasive cardiac output is measured with a validated device. Central venous blood samples are collected to determine ScvO2, and all procedures follow safety and protocolized steps to ensure data accuracy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \> 18 years
* Diagnosis of septic shock according to Sepsis-3 criteria:

Suspected or confirmed infection o Requirement for vasopressors to maintain MAP \> 65 mmHg o Serum lactate \> 2 mmol/L despite adequate fluid resuscitation

Exclusion Criteria:

* Pregnancy
* Significant valvular heart disease.
* Atrial fibrillation.
* Inadequate echocardiographic window.
* Ongoing bleeding or contraindication to fluid bolus.

Where it's running

• Menoufia University
  Menouf, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.