Assessing blood clotting issues in patients with sepsis and trauma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on critically ill patients suffering from sepsis or trauma, aiming to identify those at risk of excessive blood clot formation using Viscoelastic Testing (VET) technology. The study will evaluate the effectiveness of new blood coagulation drugs and guide the use of blood-modifying treatments at the bedside. By understanding the mechanisms behind fibrinolysis resistance, the research seeks to personalize treatment approaches to improve patient outcomes in these high-risk populations.

Why it matters

Who can join: the full rules

Sepsis/Septic shock Inclusion Criteria:

* Admission to ICU, needing at least one organ supportand principally for the management of clinically suspected Sepsis or Septic shock according to Spesis-3 criteria (including SARS-COV-2)
* Expected to remain in ICU and survive beyond the day after tomorrow

Sepsis Exclusion Criteria:

* On oral anticoagulant/antiplatelet therapy
* Not for full, active ICU support
* Death is deemed inevitable within 24 hrs

Trauma Inclusion Criteria:

* Trauma is the principal diagnosis on ICU admission
* Expected to remain in ICU and survive beyond the day after tomorrow
* Receiving respiratory support at the time of ICU admission - high-flow nasal prongs, non-invasive or invasive ventilation
* Already received, or considered at risk of needing a blood product transfusion within 24 hrs of injury

Trauma Exclusion Criteria:

* Nursing home resident
* Unsurvivable head injury
* Not for full, active ICU support
* Death is deemed inevitable within 24 hrs

Where it's running

• The Canberra hospital (ICU)
  Canberra, Australian Capital Territory, Australia Recruiting
• Liverpool Hospital (ICU)
  Liverpool, New South Wales, Australia Recruiting
• Macquarie University Hospital (ICU)
  Macquarie, New South Wales, Australia Recruiting
• Royal North Shore Hospital (ICU)
  St Leonards, New South Wales, Australia Recruiting

Study contacts

• Study coordinator: Anders Aneman, MD, PhD, EDIC, FCICM
• Email: anders.aneman@health.nsw.gov.au
• Phone: +61427915693

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.