Investigating how transposable elements affect immune aging in sepsis patients
Official title: Role of Transposable Elements in Septic Immune Aging
Run by University of California, San Francisco · NCT06809868 · Data updated 2026-11-12
This study looks at how certain genetic elements might affect the immune system and health outcomes in people with sepsis in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 116 (estimated) |
| Sponsor | University of California, San Francisco Academic / other |
| Drugs / interventions | CAR-T |
| Locations | 1 site (San Francisco, California) |
| Status | Recruiting |
| Started | February 14, 2025 |
| Main results expected | February 14, 2028 |
| Study ends | August 14, 2028 |
| Registry record updated | January 30, 2026 |
| Trial ID | NCT06809868 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 or older who are admitted to the ICU with sepsis and have a SOFA score of at least 2.
✕Probably not a fit
Patients on organ transplantation immunosuppression, those with preexisting leukopenia, or cancer patients receiving CAR-T therapy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the relationship between transposable elements and patient outcomes in individuals suffering from sepsis. It seeks to determine whether these elements contribute to premature immune aging, correlate with increased mortality, and are linked to a higher incidence of secondary infections in ICU patients. Participants will have blood samples collected for RNA and DNA sequencing without any additional interventions. The study focuses on patients admitted to the ICU with sepsis, utilizing established criteria for inclusion.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of sepsis, potentially enhancing patient outcomes.
How similar studies have gone: While the specific approach of examining transposable elements in sepsis is novel, related studies have shown the importance of immune aging in critical conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 or older * Admitted to ICU with sepsis (Sepsis 3 Criteria) * SOFA score of at least 2 at time of enrollment Exclusion Criteria: * Patients on organ transplantation immunosuppression * Patients with preexisting leukopenia * Cancer patients receiving CAR-T therapy * Patients who are under 18 years of age or otherwise deemed pediatric * Patients with an ongoing bleeding diathesis (ie: DIC, hemorrhagic shock) * Patients with a chronic hemoglobin below 7.0 * Patients who, prior to their ICU admission, are blood transfusion dependent
Where it's running
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University of California, San Francisco
San Francisco, California, United States Recruiting
Study contacts
- Principal investigator: Alexendar R Perez, M.D., Ph.D — University of California, San Francisco
- Study coordinator: Alexendar R Perez, M.D., Ph.D
- Email: Alexendar.Perez@ucsf.edu
- Phone: 415-476-1000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.