Does warming patients before surgery affect lactate levels after nephrectomy?
Official title: Effect of Preoperative Active Prewarming on Serum Lactate Levels and Perioperative Outcomes in Patients Undergoing Elective Nephrectomy: A Prospective Observational Study
Run by Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization · NCT07702487 · Data updated 2026-11-12
This observational study looks at whether warming patients before kidney removal surgery changes blood lactate and helps recovery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 128 (estimated) |
| Sponsor | Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization Academic / other |
| Locations | 1 site (Istanbul, Sisli) |
| Status | Recruiting |
| Started | November 15, 2025 |
| Main results expected | November 15, 2026 |
| Study ends | November 15, 2026 |
| Registry record updated | July 14, 2026 |
| Trial ID | NCT07702487 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–90 undergoing elective nephrectomy with ASA I–III, able to provide informed consent, and with complete pre/postoperative measurements.
✕Probably not a fit
Findings may show no difference between prewarming and no prewarming groups or no impact on the specific outcomes studied.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, single-center observational study of adults undergoing elective nephrectomy. Researchers compare patients who receive preoperative warming to those who do not, as decided by the anesthesia team in routine care. The goal is to see if prewarming influences perioperative lactate levels and outcomes such as ICU stay, transfusion needs, and complications. Data are collected from pre- and postoperative periods without altering standard clinical practice. The study duration covers one year and includes adults aged 18 to 90 with ASA I–III status.
Why it matters
Potential benefit: If prewarming is associated with lower lactate or better recovery, it could support simple, low-risk changes to perioperative care.
How similar studies have gone: Previous work in perioperative warming has suggested metabolic benefits in some settings, but data specific to nephrectomy and lactate are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Scheduled for elective nephrectomy * Adults aged 18-90 years * ASA (American Society of Anesthesiologists) physical status classification I-III * Signed informed consent form Exclusion Criteria: * Emergency nephrectomy * Concurrent additional major surgical procedure planned in the same session * Age under 18 or over 90 years * ASA physical status classification IV or higher * Incomplete preoperative records (missing pre- or postoperative measurement of at least one primary outcome variable)
Where it's running
-
Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Istanbul, Sisli, Turkey (Türkiye) Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Recovery, quality of life, and physical function after partial or radical nephrectomy
This study tests recovery, quality of life, and physical function before and after nephrectomy to see how patients fare depending on the surgery type.
-
Multimodal anesthesia for robotic kidney removal
This trial tests whether a multimodal anesthesia plan helps patients recover faster after robotic nephrectomy for cancer compared with standard anesthesia.
-
How higher blood lactate affects fat and carbohydrate metabolism
This test raises blood lactate with an IV in adults with and without metabolic syndrome to see if higher lactate lowers fat breakdown and worsens glucose tolerance.
-
R.E.C.K versus Exparel for pain control during robotic kidney removal
This will test whether intraoperative R.E.C.K or Exparel gives better pain control and reduces opioid use in adults having robotic partial or radical nephrectomy.
-
Managing body temperature during cancer surgery to reduce delirium and improve survival
This study tests if keeping older patients at a specific body temperature during major cancer surgery can help reduce confusion after surgery and improve their chances of survival.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.