How higher blood lactate affects fat and carbohydrate metabolism
Official title: Role of Elevated Lactate Levels on Lipid and Carbohydrate Metabolism.
Run by University of Castilla-La Mancha · NCT07426172 · Data updated 2026-11-12
This test raises blood lactate with an IV in adults with and without metabolic syndrome to see if higher lactate lowers fat breakdown and worsens glucose tolerance.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | University of Castilla-La Mancha Academic / other |
| Locations | 1 site (San Javier, Murcia) |
| Status | Recruiting |
| Started | January 20, 2026 |
| Main results expected | January 30, 2028 |
| Study ends | September 30, 2028 |
| Registry record updated | February 23, 2026 |
| Trial ID | NCT07426172 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults (>18) who are physically active, able to exercise, willing to undergo IV infusions and OGTTs, and either meet IDF criteria for metabolic syndrome or are metabolically healthy for the comparison group.
✕Probably not a fit
Patients with chronic illnesses that prevent exercise, pregnant women, or those judged unsuitable by the investigator are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study will enroll 10 metabolically healthy and 10 metabolically impaired adults matched for sex and activity. Metabolically healthy participants will undergo two visits—one with intravenous sodium lactate to raise blood lactate to levels seen in metabolic syndrome and one with saline—while metabolically impaired participants will undergo the saline visit. Each visit includes a 150-minute basal period, an exercise bout, and a 2-hour oral glucose tolerance test, with measurements of insulin sensitivity, substrate oxidation by indirect calorimetry, and glycerol/glucose turnover using stable isotopes. The design compares acute effects of elevated lactate on lipolysis and carbohydrate metabolism at rest, during exercise, and after glucose intake.
Why it matters
Potential benefit: If successful, this could show whether lowering lactate or blocking lactate signaling might improve fat breakdown and blood sugar control in people with metabolic syndrome.
How similar studies have gone: Prior mechanistic and animal studies suggest lactate can act as a metabolic signal, but directly raising blood lactate in humans to mimic metabolic syndrome and measure effects on lipolysis and glucose tolerance is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women * \>18 years of age * Women non-pregnant or taking contraceptive medication * Physically active according to WHO's guidelines * Metabolic syndrome as IDF 2009 criteria (Alberti et al., Circulation) * Written and verbal consent to participation Exclusion Criteria: * Chronic illness that prevents them from exercising * Affected blood samples at screening, as assessed by the PI * Assessed as unsuitable by PI
Where it's running
-
Facultad de Ciencias del Deporte
San Javier, Murcia, Spain Recruiting
Study contacts
- Principal investigator: Ricardo Mora Rodriguez, PhD — University of Castilla-La Mancha
- Study coordinator: Ricardo MORA RODRIGUEZ, PhD
- Email: ricardo.mora@uclm.es
- Phone: +34675424515
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.