Does the amount of water in brain tissue on a CT scan help predict outcomes after IV thrombolysis for acute ischemic stroke?
Official title: Quantitative Net Water Uptake as a Predictor of Functional Outcomes After Intravenous Thrombolysis in Acute Ischemic Stroke International Multicenter Observational Retrospective Study
Run by Sigmund Freud PrivatUniversitat · NCT07299981 · Data updated 2026-11-12
This study tests whether measuring quantitative net water uptake on the first CT scan can predict how well patients do after receiving intravenous thrombolysis for acute ischemic stroke.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Sigmund Freud PrivatUniversitat Academic / other |
| Locations | 1 site (Vienna) |
| Status | Recruiting |
| Started | February 1, 2026 |
| Main results expected | April 1, 2027 |
| Study ends | July 1, 2027 |
| Registry record updated | July 16, 2026 |
| Trial ID | NCT07299981 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with acute ischemic stroke who were treated with intravenous thrombolysis and have suitable baseline and follow-up imaging (CT or MRI) with ASPECTS data available.
✕Probably not a fit
Patients with missing imaging, poor imaging quality, large preexisting infarcts, or those who did not meet inclusion criteria may not benefit from NWU-based predictions.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter observational study analyzes acute ischemic stroke patients treated with IV thrombolysis to see if net water uptake on initial non-contrast CT predicts functional outcomes. Researchers will compare NWU values with subsequent imaging 12–24 hours after treatment and relate them to final infarct size and clinical outcomes. The study uses existing imaging data, with no experimental interventions, to explore NWU as a potential tissue clock biomarker. It aims to clarify whether NWU modifies the treatment effect of IV thrombolysis. Results could help refine prognostication and decision-making in this patient group.
Why it matters
Potential benefit: If NWU proves predictive, clinicians may better estimate outcomes after IV thrombolysis and tailor early care and counseling.
How similar studies have gone: Previous work suggests NWU relates to tissue injury and outcomes, but this study will test its role specifically as a treatment-modifying biomarker for IVT.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Acute ischemic stroke treated with intravenous thrombolysis * Imaging with non-contrast cranial CT on admission * Follow-up imaging with non-contrast cranial CT or MRI 12-24 hours after IVT * Final Infarct volume \> 5ml * ASPECTS available Exclusion Criteria: * Known use of oral anticoagulation (OAC) on admission * Preexisting ischemic infarction on admission non-contrast cranial CT * Patients with large vessel occlusion AIS who underwent mechanical thrombectomy * Low imaging quality precluding radiological measurements * Severe white matter lesions precluding radiological measurements * No ASPECTS
Where it's running
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Department of Neurology, St. John's Hospital, Vienna, Austria, Vienna, 1020
Vienna, Austria Recruiting
Study contacts
- Study coordinator: Marek Sykora
- Email: marek.sykora@med.sfu.ac.at
- Phone: +431211215183
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.