Discovering new biomarkers and treatment targets for osteoporosis using advanced technologies
Identification of New Biomarkers and Potential Therapeutic Targets in Clinical Osteoporosis Using Omics Technologies
This study is trying to find new ways to diagnose and treat osteoporosis by looking at bone and blood samples from postmenopausal women with hip fractures and comparing them to women with osteoarthritis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Sex | Female |
| Sponsor | National and Kapodistrian University of Athens Academic / other |
| Locations | 1 site (Kifissia, Attica) |
| Trial ID | NCT06525688 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify novel biomarkers and therapeutic targets for osteoporosis by utilizing omics technologies, specifically proteomics and metabolomics. It will analyze bone and plasma samples from 60 postmenopausal women, comparing those with osteoporotic hip fractures to a control group with osteoarthritis. The study seeks to uncover the underlying mechanisms of osteoporosis and validate potential diagnostic and therapeutic biomarkers through advanced analytical techniques. The findings could lead to improved diagnosis and treatment strategies for osteoporosis.
Who should consider this trial
Good fit: Ideal candidates for this study are postmenopausal women with osteoporotic hip fractures or those with hip osteoarthritis undergoing total hip replacement.
Not a fit: Patients who have previously experienced osteoporotic fractures or have severe cardiovascular, pulmonary, autoimmune, or urinary system conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide new diagnostic tools and treatment options for patients suffering from osteoporosis.
How similar studies have performed: Other studies utilizing omics technologies have shown promise in identifying biomarkers for various conditions, suggesting potential success for this novel approach in osteoporosis.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Postmenopausal Female Patients with osteoporotic subcapital femoral neck fracture (Arm 1) * Postmenopausal Female Patients with hip osteoarthritis that will undergo Total Hip Replacement (Arm 2) Exclusion Criteria: * Patients that have undergone before osteoporotic fractures * Patients with severe cardiovascular, pulmonary, autoimmune, or urinary system conditions
Where this trial is running
Kifissia, Attica
- Laboratory for Research of the Musculoskeletal System — Kifissia, Attica, Greece (Recruiting)
Study contacts
- Study coordinator: Efstathios Chronopoulos
- Email: stathi24@yahoo.gr
- Phone: 00306944837793
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.