Digital mental health support for patients with inflammatory bowel disease

Digital Support for Mental Health Intervention in Patients With Inflammatory Bowel Disease

Not applicable Interventional University of Chicago · NCT06575660

This study is testing a new app that uses virtual reality and AI to see if it can help people with inflammatory bowel disease who are feeling anxious or depressed.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment28 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Chicago Academic / other
Locations1 site (Chicago, Illinois)
Trial IDNCT06575660 on ClinicalTrials.gov

What this trial studies

This exploratory study investigates the feasibility and acceptability of a digital wellness application that combines artificial intelligence and virtual reality to provide mental health support for patients with inflammatory bowel disease (IBD) experiencing mild to moderate anxiety or depression. The application, called XAIA, delivers personalized mental health sessions in a mixed-reality environment. Participants will engage in a single session, and their experiences will be assessed through surveys and interviews, alongside pre- and post-session evaluations of pain and anxiety levels.

Who should consider this trial

Good fit: Ideal candidates are English-speaking adults aged 18 and older with a diagnosis of inflammatory bowel disease and mild to moderate anxiety or depression.

Not a fit: Patients with severe motion sickness, significant sensory impairments, or those unable to engage with the VR technology may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could enhance mental health support for IBD patients, potentially improving their overall well-being and quality of life.

How similar studies have performed: While the use of AI and VR for mental health support is an emerging field, this specific approach is novel and has not been extensively tested in similar populations.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18+ years of age
* Patients with Inflammatory Bowel Disease (Crohn's Disease or Ulcerative Colitis)
* English-speaking
* Patients with score of 5-14 on General Anxiety Disorder-7 (GAD-7) questionnaire or 5-19 on Patient Health Questionnaire-9 (PHQ-9) within 3 months
* Able to provide written consent

Exclusion Criteria:

* Unwilling and/or unable to participate
* Non-English speakers
* Self-reported history of severe motion sickness
* The presence of a facial/head deformity that will prohibit comfortably wearing of a VR headset
* Legally blind or deaf
* Having had a seizure in the past year
* Unable to understand the instructions or to consent to participation in the study.
* Those who are pregnant

Where this trial is running

Chicago, Illinois

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Inflammatory Bowel DiseasesAnxietyDepressionUlcerative ColitisCrohn Disease
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.