Differences in risk, prognosis, and metabolism between early- and late-onset pancreatic neuroendocrine tumors
Official title: Study in Risk Factors, Prognosis, Clinicopathological and Metabolic Characteristics Between Early- and Late-Onset Pancreatic Neuroendocrine Tumors: A Multicenter Retrospective Study
Run by Qilu Hospital of Shandong University · NCT07136701 · Data updated 2026-11-12
This study looks at whether early-onset PanNETs have different clinical and metabolic features and outcomes than late-onset PanNETs by reviewing patient records from multiple centers.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 600 (estimated) |
| Sponsor | Qilu Hospital of Shandong University Academic / other |
| Locations | 2 sites (Jinan, Shandong and 1 other locations) |
| Status | Recruiting |
| Started | August 31, 2025 |
| Main results expected | June 30, 2026 |
| Study ends | July 31, 2027 |
| Registry record updated | August 13, 2026 |
| Trial ID | NCT07136701 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older with histologically confirmed pancreatic neuroendocrine tumors who have undergone surgical resection or biopsy.
✕Probably not a fit
Patients with incomplete pathological data, prior antitumor treatment before presentation, pancreatic neuroendocrine carcinoma, or concurrent malignancies may have limited applicability of findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter retrospective cohort study analyzes existing medical records to compare early-onset pancreatic neuroendocrine tumors (EO-PanNETs) with late-onset PanNETs (LO-PanNETs) across risk factors, clinicopathological traits, and metabolic characteristics. Researchers will examine survival, recurrence, and other prognostic indicators, using matched comparisons to nonmalignant controls when possible. Data will be drawn from pathology reports, clinical histories, and follow-up information to characterize distinctions between EO- and LO-PanNETs. The study is observational and relies on retrospective data without an intervention. Findings aim to clarify whether EO-PanNETs represent a distinct disease subset with different prognosis or metabolic associations.
Why it matters
Potential benefit: If successful, the study could improve understanding of how EO-PanNETs differ from LO-PanNETs, potentially guiding earlier recognition and tailored follow-up.
How similar studies have gone: Previous observational work has explored phenotypic and prognostic differences in PanNETs, but this study adds a multicenter retrospective comparison focused on onset age and metabolic features.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years or older; histopathologically confirmed pancreatic neuroendocrine tumor by surgical resection or biopsy. Exclusion Criteria: * Pancreatic neuroendocrine carcinoma; incomplete pathological data; received antitumor treatment prior to presentation; with other malignanies or malignant history.
Where it's running
-
Qilu Hospital of Shandong University
Jinan, China Recruiting -
Qilu Hospital of Shandong University
Jinan, Shandong, China Not yet recruiting
Study contacts
- Study coordinator: Hanxiang Zhan, MD. PhD.
- Email: zhanhanxiang@hotmail.com
- Phone: +86 18560085156
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.