Brain network patterns in muscle pain patients measured by MEG

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center prospective cohort will enroll at least 1,000 muscle pain patients and 200 healthy controls to study neural oscillations and functional connectivity using magnetoencephalography. Participants will have MEG sessions (working-memory task, resting-state, and stimulus-evoked paradigms), MRI, and extensive clinical scales at baseline, with follow-ups at 1, 3, and 6 months to track pain and function. Data will be analyzed with multivariate and mixed-effects models to build a prognosis model for pain outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Meet the diagnostic criteria for muscle pain as specified in the Clinical Diagnosis Guidelines: Volume of Physical Medicine and Rehabilitation
2. VAS score ≥ 3 points.
3. Aged 18-70 years.
4. Lesions located in the soft tissues of the neck, shoulder, or lumbodorsal region, accompanied by tender points.
5. Able to understand and cooperate in completing the scales and undergoing MEG and MRI examinations.
6. Has signed the informed consent form

Exclusion Criteria:

1. History of previous related disorders in the neck, shoulder, or lumbodorsal region.
2. Recent use of medications that significantly affect central excitability and inability to stabilize the condition.
3. Contraindications to MEG or MRI.
4. Presence of ferromagnetic metals implanted in the body (e.g., metal dentures, aneurysm clips, pacemakers, stents, steel plates, etc.), claustrophobia that prevents MEG examination, or failed data acquisition.
5. Concurrent severe diseases of the heart, brain, kidney, or other major organs.
6. History of muscle diseases such as tuberculosis, rheumatism, or infection.
7. Obvious cognitive impairment or communication difficulties that prevent cooperation with this study.

Where it's running

• Qilu hospital, Jinan, Shangdong
  Jinan, Shandong, China Recruiting

Study contacts

• Study coordinator: Xiaofei Zhang
• Email: xfeizhang2025@163.com
• Phone: 86-15563139097

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.