Dexmedetomidine versus dexamethasone added to ropivacaine for supraclavicular nerve block in upper‑limb surgery
Official title: Comparative Analysis Of Dexmedetomidine And Dexamethasone As An Adjuvant To 0.5%Ropivacaine On Onset Of Ultrasound Guided Supraclavicular Brachial Plexus Block In Patients Undergoing Upper Limb Surgeries
Run by Sahiwal medical college sahiwal · NCT07290595 · Data updated 2026-11-12
This test compares two medicines added to ropivacaine to see which gives faster onset and longer pain relief for adults having upper‑limb surgery with an ultrasound‑guided supraclavicular nerve block.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 66 (estimated) |
| Sponsor | Sahiwal medical college sahiwal Government |
| Locations | 1 site (Sāhīwāl, Punjab Province) |
| Status | Recruiting |
| Started | January 13, 2025 |
| Main results expected | February 12, 2026 |
| Study ends | March 12, 2026 |
| Registry record updated | December 23, 2025 |
| Trial ID | NCT07290595 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–70 years old, ASA class I–III, non‑pregnant, scheduled for upper‑limb surgery below the mid‑humerus and willing to receive an ultrasound‑guided supraclavicular brachial plexus block.
✕Probably not a fit
People with ischemic heart disease, bleeding disorders, infection at the block site, pre‑existing upper‑limb neuropathy, allergy to the study drugs, pregnant patients, or those unable to travel to the study site are unlikely to be eligible or benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults scheduled for upper‑limb surgery below the mid‑humerus are randomized to receive 28 ml of 0.5% ropivacaine with either 1 mcg/kg dexmedetomidine or 8 mg dexamethasone using an ultrasound‑guided supraclavicular brachial plexus block. Drugs are prepared and coded by one anesthetist so the clinician performing and observing the block is blinded to the assignment. The trial records onset time of sensory and motor block, duration of postoperative analgesia, and hemodynamic effects including bradycardia and hypotension. Standard monitoring and exclusion criteria (pre‑existing neuropathy, infection at the site, ischemic heart disease, coagulopathy, pregnancy, or allergy) are applied to maintain safety.
Why it matters
Potential benefit: If one adjuvant proves superior, patients could get faster‑acting, longer‑lasting regional anesthesia with less need for opioids and improved postoperative comfort.
How similar studies have gone: Numerous prior trials have shown that both perineural dexmedetomidine and dexamethasone can prolong peripheral nerve block duration, but head‑to‑head comparisons have produced mixed results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria * Patients scheduled for upper limb surgery below mid-humerus level * Patients aged 18 to 70 years * Patients with ASA class I, II and III * Male and non-pregnant females Exclusion Criteria * Patients refusal * Patients with pre-existing peripheral neuropathy of the upper limb * Patients with the Infection at block site * Patients with history of ischemic heart disease * Patients with bleeding disorder or deranged coagulation profile * Patients with known history of allergy to local anaesthetic or any other drugs used
Where it's running
-
Sahiwal Medical College, Sahiwal
Sāhīwāl, Punjab Province, Pakistan Recruiting
Study contacts
- Study coordinator: Dr Maryam Maqsood, MBBS
- Email: maryammaqsood448@gmail.com
- Phone: 00923347036271
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.