Developing blood tests for predicting complications in stem cell transplantation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) to develop new blood tests that can predict the onset of acute graft-versus-host disease (aGvHD) and leukemia relapse. By collecting and analyzing blood samples from 300 transplant recipients at various stages of their treatment, the study aims to identify biomarkers that can help personalize prophylaxis and early interventions. The research will also create a valuable resource of clinically annotated samples for future studies in the transplant research community.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Any recipient of allogeneic haematopoietic stem cell transplantation (HSCT)
* Children/infants may participate, there is no age restriction
* Patients participating in other clinical trials remain eligible

Exclusion Criteria:

* Weight \<5kg
* Recipients of autologous stem cell transplants

Where it's running

• Manchester Royal Infirmary
  Manchester, United Kingdom Recruiting
• Royal Manchester Children's Hospital
  Manchester, United Kingdom Recruiting
• The Christie NHS Foundation Trust
  Manchester, United Kingdom Recruiting

Study contacts

• Principal investigator: Mark Williams — CRUK Manchester Institute
• Study coordinator: Mark Williams
• Email: mark.williams-4@cruk.manchester.ac.uk
• Phone: +441613063240

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.