CTX340 in Adults with Uncontrolled Hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a dose-escalation, early-phase study testing CTX340 in adults with hypertension who remain above target blood pressure despite multiple therapies. Participants will be randomized to receive CTX340 or placebo by IV infusion, with monitoring for safety, tolerability, and preliminary efficacy. The trial includes two phases (Phase 1/2) and aims to identify a safe dose range and signals of blood pressure reduction. Eligible individuals are adults 18 to 75 on at least four antihypertensive medications, including a diuretic, and with certain blood pressure criteria. The study is conducted at two sites in Florida and is sponsored by CRISPR Therapeutics AG.

Why it matters

Who can join: the full rules

Key Inclusion Criteria:

1. Age: ≥18 and ≤75 years.
2. Body mass index ≤40 kg/m2.
3. 24-hour mean ambulatory blood pressure monitoring (ABPM) systolic blood pressure (SBP) measurement of ≥130 mm Hg but ≤160 mm Hg despite treatment
4. Be on treatment with ≥4 antihypertensive therapies at effective doses, of which ≥1 must be a diuretic.
5. Participants who at any point had childbearing potential must currently be postmenopausal
6. All participants capable of producing sperm must agree to the use of an acceptable method of effective contraception and their partners with childbearing potential should also agree to use an effective method of contraception.

Exclusion Criteria:

1. Serum aldosterone and direct renin concentration (or plasma renin activity \[PRA\]) suggestive of primary aldosteronism
2. Mean diastolic blood pressure (DBP) ≤65 mm Hg on screening ABPM.
3. Participants with vascular cause of hypertension which may be amendable to revascularization
4. Participants with treatable/reversible causes of uncontrolled hypertension
5. History of renal artery denervation within past 12 months.
6. Orthostatic hypotension
7. Complete blood count (CBC) outside the specified ranges per protocol.
8. Evidence of liver disease
9. History of a significant coagulation disorder.
10. Uncontrolled or untreated thyroid disease

Where it's running

• Research Site 1
  Port Orange, Florida, United States Recruiting
• Research Site 2
  Melbourne, Australia Recruiting

Study contacts

• Study coordinator: Clinical Trials
• Email: medicalaffairs@crisprtx.com
• Phone: 877-214-4634

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.