Creating models of brain tumors from patient samples
Establishment of Pre-clinical Stem Line and Tumoroid Models of Brain Tumors
This study is trying to create models of brain tumors from patient samples to find new treatment options for adults with aggressive brain tumors like glioblastoma.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique Hopitaux De Marseille Academic / other |
| Locations | 1 site (Marseille) |
| Trial ID | NCT06045065 on ClinicalTrials.gov |
What this trial studies
This observational study aims to generate tumoroids and stem-like cell lines from patient tumor samples to better understand brain metastases and diffuse gliomas. By utilizing fresh tumor sampling, the study seeks to identify new therapeutic targets and develop innovative treatment strategies to overcome resistance in these aggressive brain tumors. The focus is on glioblastoma, which has a poor prognosis and limited treatment options. The research will involve adult patients eligible for neurosurgery who have undergone neuro-imaging for brain tumors.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients with brain tumors who are eligible for neurosurgery.
Not a fit: Patients with unresectable tumors will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to the development of more effective treatments for patients with brain tumors.
How similar studies have performed: While similar approaches have been explored, this specific methodology of generating tumoroids from patient samples is innovative and may provide new insights into treatment resistance.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients * Brain tumor neuro-imaging * Eligible for neurosurgery Exclusion Criteria: * unresectable tumor
Where this trial is running
Marseille
- Assistance publique hopitaux de marseille — Marseille, France (Recruiting)
Study contacts
- Study coordinator: Anaïs Maugard
- Email: anais.maugard@ap-hm.fr
- Phone: +33491435186
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.