Creatine supplementation, with or without multicomponent exercise, for people over 75
Official title: Impact of Creatine Monohydrate Micronized Supplementation With or Without Multicomponent Training in Older Adults.
Run by Fundacion Miguel Servet · NCT06677359 · Data updated 2026-11-12
This trial will test whether creatine supplements, alone or combined with multicomponent exercise, improve strength, mobility, and thinking in people aged 75 and older.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 75 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Fundacion Miguel Servet Academic / other |
| Locations | 1 site (Pamplona, Navarre) |
| Status | Recruiting |
| Started | November 30, 2024 |
| Main results expected | November 1, 2025 |
| Study ends | December 1, 2026 |
| Registry record updated | June 12, 2025 |
| Trial ID | NCT06677359 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people aged 75 or older who can walk (with or without assistance), have a Barthel Index > 60, a life expectancy of at least six months, and can give informed consent (or have a representative).
✕Probably not a fit
Patients with advanced global deterioration (GDS 6-7), dysphagia, medical contraindications to exercise, or recent supervised training are unlikely to benefit or are excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Older adults (75+) are randomized to receive either creatine monohydrate or placebo, and concurrently either a multicomponent training program or no supervised training, to create four comparison groups. Supplementation is delivered over a short-term protocol (about five weeks) while functional, cognitive, and strength outcomes are measured before and after the intervention. The study excludes people with advanced dementia, swallowing problems, recent supervised training, or medical conditions incompatible with exercise. All visits and training take place at Hospital Universitario de Navarra and outcomes will compare the added effects and safety of creatine with and without exercise.
Why it matters
Potential benefit: If successful, the intervention could improve physical function, strength, and possibly cognition in very old adults, helping maintain independence.
How similar studies have gone: Previous trials have shown creatine can improve muscle strength and some functional measures in older adults, while cognitive benefits are less consistent and combination with multicomponent training is less well studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 75 years or older. * Able to ambulate with or without personal/technical assistance. * Life expectancy ≥ 6 months. * Barthel Index \> 60. * Informed consent by patients, or legal representatives. Exclusion Criteria: * Global Deterioration Scale (GDS 6-7). * Intolerance or allergy foods or drugs. * Deglutition problems (Dx: dysphagia) * Any pathological or metabolic condition incompatible with physical exercise. * Creatine supplementation for less than 6 weeks. * Consumption of more than 200 mg of caffeine daily. * Supervised physical training.
Where it's running
-
Hospital Universitario de Navarra
Pamplona, Navarre, Spain Recruiting
Study contacts
- Principal investigator: Nicolas Martinez-Velilla, PhD — Navarrabiomed-Fundación Miguel Servet-Hospital de Navarra
- Study coordinator: Nicolas Martinez-Velilla, PhD
- Email: nicolas.martinez.velilla@navarra.es
- Phone: 00 34 848422222
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.