See if short-term supervised resistance training improves muscle health and function in frail older adults with type 2 diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial investigates the link between skeletal muscle mitochondrial dysfunction and frailty in older adults and whether a short, supervised resistance training intervention can improve muscle bioenergetics and physical performance. It includes older adults with frailty and type 2 diabetes, as well as control groups of healthy young and older adults. Participants will undergo a brief resistance training program and assessments of muscle function and metabolic biomarkers. The study aims to clarify cellular mechanisms related to frailty and the potential benefits of exercise for this population. Outcomes focus on feasibility, safety, and changes in muscle health and functional measures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Inclusion criteria for young controls

  * Healthy young adults (18-35 years old)
  * Without any pathology or treatment
* Inclusion criteria for older controls

  * Healthy older adults (65 years or older)
  * Not currently enrolled in a resistance training program
* Inclusion criteria for cases

  * Age over 65 years
  * Diagnosis of frailty or robustness
  * Diagnosis of type 2 diabetes mellitus
  * Glycosylated hemoglobin (HbA1c) less than 9%
  * Treatment with metformin
  * Not currently enrolled in a resistance training program

Exclusion Criteria:

* Exclusion criteria for young controls

  * Pregnancy or suspected pregnancy
  * Body mass index greater than 35 kg/m2
  * Treatment within the last 30 days with oral corticosteroids
  * Edema or severe fluid regulation disorders that could alter bioimpedance results
  * Allergy to the local anesthetic mepivacaine
  * Prostheses, metal implants, or surgical staples lodinated or barium contrast for other imaging tests within the last 7 days
* Exclusion criteria for older controls

  * Decompensated and uncontrolled chronic diagnoses
  * Body mass index greater than 35 kg/m2
  * Treatment within the last 30 days with oral corticosteroids
  * Systemic diseases, active oncological disease, liver cirrhosis, untreated hypothyroidism, or severe chronic obstructive pulmonary disease (COPD).
  * Severe edema or fluid regulation disorders that could alter bioimpedance results
  * Allergy to the local anesthetic mepivacaine
  * Prostheses, metal implants, or surgical staples Iodinated or barium contrast for other imaging tests in the last 7 days
* Exclusion criteria for cases

  * Diagnosis of pre-frailty
  * Age over 80 years
  * Body mass index greater than 35 kg/m2
  * Time since onset of diabetes mellitus type 2 less than 10 years
  * Treatment with insulin
  * Treatment with allopurinol
  * Treatment with anticoagulant or antiplatelet drugs
  * Treatment within the last 30 days with oral corticosteroids
  * Advanced chronic complications of diabetes mellitus type 2 :

Renal failure (clearance \<30 ml/min/m2) Macroalbuminuria greater than 200 mg/g Ischemic vascular diseases (acute myocardial infarction) Myocardial infarction, angina, stroke) Proliferative retinopathy or laser therapy Ulcerated diabetic foot or lower limb amputations, except for digital amputations

* Systemic diseases, active oncological disease, liver cirrhosis, untreated hypothyroidism, or severe chronic obstructive pulmonary disease
* Physical limitations in the lower limbs (acute or acute-on-chronic inflammatory processes, limited joint range of motion, chronic pain (visual analogue scale for pain \> or = 4, etc.)
* Senile dementia
* Edema or severe fluid regulation disorders that may alter bioimpedance results
* Allergy to the local anesthetic mepivacaine
* Pacemaker, metallic prostheses or implants, surgical staples, and radiopaque tubes or catheters Iodinated or barium contrast for other imaging tests within the last 7 days

Where it's running

• University of Valencia/Hospital Clínico Universitario de València,
  Valencia, Spain Recruiting

Study contacts

• Study coordinator: Maria Carmen Gómez Cabrera, Doctor in Physiology
• Email: carmen.gomez@uv.es
• Phone: +34-666871805

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.