L‑serine supplements with or without strength training for older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, double‑blind, controlled interventional study with three parallel groups (placebo, L‑serine, and L‑serine plus strength training) run over 48 weeks. Healthy, independently mobile men and women aged 65–85 will undergo cognitive testing, physical performance testing, MRI and EEG, and blood biomarker analyses at multiple time points. The primary outcome is change in a composite cognitive score (RBANS), with secondary outcomes including brain structure and function, markers of oxidative stress and immune function, muscle mass, and physical performance. The design allows comparison of nutritional supplementation alone versus combined multimodal intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women between the ages of 65 and 85
* Mini-Mental-State \>23
* Independently mobile, without aids (walker, cane, etc.)

Exclusion Criteria:

* Chronic diseases that contraindicate medical training therapy
* Regular strength training (\>1x/week) in the last 6 months before confinement
* Frailty Index ≥ 3
* Lack of written consent to test physical performance
* Regular use of Cortison-containing medications or Antibiotika
* MR-specific exclusion criteria: claustrophobia, metal equipment or other magnetic Material in or on the body
* Non-compliance with the study protocol: \<70% of the planned L-serine administration, \<70% of the strength training

Where it's running

• NuTraLab
  Vienna, State of Vienna, Austria Recruiting

Study contacts

• Study coordinator: Karl-Heinz Wagner, Prof.
• Email: karl-heinz.wagner@univie.ac.at
• Phone: +43-1-4277-54930

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.