Cord-blood PRP therapy to help thin or scarred uterine lining

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study investigates the use of umbilical cord blood–derived platelet-rich plasma (hUC-PRP) injected into the uterine lining to improve endometrial thickness and pattern in women with endometrial pathologies. Building on prior pilot data, the study plans to enroll 35 participants who have persistent thin endometrium despite estrogen therapy or have Asherman syndrome. Eligible participants are women aged 18–48 with BMI 18–35, and endometrium <5 mm under treatment or confirmed Asherman syndrome, excluding active infections or other major contraindications. The intervention involves hysteroscopic administration of hUC-PRP, with outcomes focused on endometrial restoration and potential future fertility impact. The investigation is conducted under the Fundación IVI at IVI Valencia, with standard safety screening and follow-up procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age between 18 and 48 years at the time of recruitment
* body mass index (BMI): ≥ 18 kg/m2 and ≤ 35 kg/m2
* endometrial thickness \< 5 mm despite estrogen administration according to each clinic's routine practice for 10 or more days and/or evidence of Asherman syndrome.

Exclusion Criteria:

* Active genital infection at the time of recruitment
* chronic endometritis
* known endometrial pathology
* psychiatric disorder that could hinder study follow-up
* positive results on viral safety testing (HBsAg, HBcAb, HCV, HIV-1, HIV-2, syphilis)
* presence of any syndrome or condition that, in the opinion of the principal investigator, could pose a risk to the study or to the patient
* any clinically significant abnormality detected during the recruitment process
* simultaneous participation in another clinical study that could affect the objectives of the present study, or prior participation in this same study.

Where it's running

• IVI Valencia
  Valencia, Spain Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using bone marrow stem cells to treat abnormal endometrium conditions

  This study is testing if using a special treatment to help bone marrow stem cells can improve conditions like Asherman's Syndrome and help women get pregnant better than standard care.

  Recruiting Early Phase 1 Yale University · Orange, Connecticut · NCT05343572

• Impact of vaginal bacteria on pregnancy success after embryo transfer

  This study is trying to see if the types of bacteria in the vagina affect the chances of getting pregnant after an embryo transfer for women undergoing fertility treatments.

  Recruiting at 10 sites Fundación IVI · Barcelona and 9 other locations · NCT06643065

• Effects of IVF Hormonal Therapy on Endometrial Health

  This study is testing how different hormonal treatments used in IVF affect the health of the uterus to see if they can improve the chances of successful implantation.

  Recruiting Fundación IVI · Valencia, Valencia · NCT06280560

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.