Using bone marrow stem cells to treat abnormal endometrium conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of mobilizing autologous bone marrow stem cells using Plerixafor for treating Asherman's Syndrome, Atrophic Endometrium, and Recurrent Implantation Failure. Participants will undergo treatment and their endometrial thickness and implantation rates will be compared to historic controls receiving standard care. The study also aims to assess ongoing pregnancy and live birth rates, as well as changes in menstrual bleeding patterns and endometrial blood flow over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy, non pregnant females
* ages ≥18 and ≤40 years old at time of enrollment
* with either AS, AE, or RIF

  1. For AS: surgical history of intrauterine trauma/infection, hypo/amenorrhea, intra-uterine adhesions
  2. for AE: US documentation of persistent, \<6mm endometrial thickness
  3. for RIF: failure to achieve a clinical pregnancy after transfer of at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman under 40 years and currently being treated at Yale Fertility Clinic

Exclusion Criteria:

* Presence of hydrosalpinx (diagnosed by radiographic or ultrasound imaging)
* Endometriosis (diagnosed by previous surgery,)
* Diminished ovarian reserve (AMH\<1ng/ml or follicle stimulating hormone (FSH)\>10)
* History of genital tuberculosis or any ultrasound evidence of congenital uterine anomaly
* Submucous or intracavitary fibroid, polyps
* Currently pregnant
* Personal history of thrombophilia or sickle cell disease
* Inability to provide informed consent

Where it's running

• Yale Fertility Center
  Orange, Connecticut, United States Recruiting

Study contacts

• Principal investigator: Hugh Taylor, MD — Yale University
• Study coordinator: Hugh S Taylor, MD
• Email: hugh.taylor@yale.edu
• Phone: (203)-785-6949

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Cord-blood PRP therapy to help thin or scarred uterine lining

  This study tests whether umbilical cord blood–derived platelet-rich plasma can improve the thickness and appearance of the endometrium in women with Asherman syndrome, endometrial atrophy, or a thin lining.

  Recruiting Fundación IVI · Valencia · NCT07697924

• Comparing timing of embryo transfer in women with recurrent implantation failure

  This study is testing if timing frozen embryo transfers based on a special test can help women with repeated implantation failures get pregnant more successfully than using the usual timing methods.

  Recruiting The University of Hong Kong · Hong Kong · NCT06762626

• Mannose-binding lectin levels and repeated pregnancy or implantation failure

  This project will test whether low blood levels of mannose-binding lectin are linked to repeated pregnancy loss, repeated failed embryo transfers after IVF/ICSI/FET, or other unexplained infertility in people with three consecutive pregnancy failures.

  Recruiting Aalborg University Hospital · Aarhus · NCT05169541

• Genetic testing to improve pregnancy rates in women with repeated implantation failure

  This study tests if a genetic test for embryos can help women who have had multiple failed pregnancies get pregnant more easily and have healthier pregnancies.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT03900780

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.