Effects of IVF Hormonal Therapy on Endometrial Health
Official title: Impact of Controlled Ovarian Stimulation and Luteal Phase Support on Endometrial Receptivity and Endometrial Senescent Cell Pathological Accumulation: Pilot Study
Run by Fundación IVI · NCT06280560 · Data updated 2026-11-12
This study is testing how different hormonal treatments used in IVF affect the health of the uterus to see if they can improve the chances of successful implantation.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 60 (estimated) |
| Sponsor | Fundación IVI Academic / other |
| Locations | 1 site (Valencia, Valencia) |
| Status | Recruiting |
| Started | February 1, 2024 |
| Main results expected | December 30, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | September 4, 2026 |
| Trial ID | NCT06280560 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include subfertile women aged 18-45 undergoing IVF treatment with a BMI between 18.5 and 30.
✕Probably not a fit
Patients with uterine diseases affecting the endometrial cavity or those with systemic or endocrine disorders may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates how hormonal therapies used in in vitro fertilization (IVF) impact endometrial receptivity and the accumulation of senescent cells in the endometrium. It compares outcomes from controlled ovarian stimulation combined with luteal phase support, hormonal replacement therapy, and natural cycles. The study aims to understand whether elevated hormone levels during these treatments lead to changes in the endometrial environment that could affect implantation success. By analyzing these effects, the research seeks to provide insights into optimizing IVF protocols for better patient outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved IVF protocols that enhance implantation rates and pregnancy outcomes for patients.
How similar studies have gone: While the specific approach of this study is novel, previous studies have indicated that hormonal levels can significantly affect endometrial receptivity, suggesting potential for meaningful insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Study group (subfertile IVF patients). * Inclusion Criteria: Women aged 18-45 years, BMI ≥ 18.5- 30. * Exclusion criteria: Women presenting any uterine disease that affects the endometrial cavity, or with a thin or irregular endometrium, altered karyotypes, thrombophilias, or uncorrected systemic or endocrine diseases will be excluded. Endometrial receptivity reference group (oocyte donors). * Inclusion criteria: women aged between 18 and 35 years, BMI ≥ 18.5- 25. * Exclusion criteria: Any cases of DIU presence, hormonal contraceptives at least during the last three months, altered karyotypes, thrombophilias, or uncorrected systemic or endocrine diseases will be excluded.
Where it's running
-
IVI-RMA Valencia Clinic
Valencia, Valencia, Spain Recruiting
Study contacts
- Principal investigator: Francisco Domínguez Hernández, PhD — IVI Foundation, Valencia, Valencia, Spain
- Study coordinator: Francisco Domínguez Hernández, PhD
- Email: francisco.dominguez@ivirma.com
- Phone: +34963903305
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Evaluating a non-invasive test for endometrial receptivity in patients with implantation failure
This study is testing a new blood test called the Ora test to see if it can help couples who have had trouble with embryo implantation during IVF by finding the best time for embryo transfer.
-
Cord-blood PRP therapy to help thin or scarred uterine lining
This study tests whether umbilical cord blood–derived platelet-rich plasma can improve the thickness and appearance of the endometrium in women with Asherman syndrome, endometrial atrophy, or a thin lining.
-
Impact of vaginal bacteria on pregnancy success after embryo transfer
This study is trying to see if the types of bacteria in the vagina affect the chances of getting pregnant after an embryo transfer for women undergoing fertility treatments.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.