Impact of vaginal bacteria on pregnancy success after embryo transfer
Official title: The Influence of the Vaginal Microbiome on Clinical Pregnancy in Patients Undergoing a Euploid Embryo Transfer: A Prospective Blinded Multicentre Cohort Study
Run by Fundación IVI · NCT06643065 · Data updated 2026-11-12
This study is trying to see if the types of bacteria in the vagina affect the chances of getting pregnant after an embryo transfer for women undergoing fertility treatments.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | Women only |
| Enrollment | 1573 (estimated) |
| Sponsor | Fundación IVI Academic / other |
| Locations | 10 sites (Barcelona and 9 other locations) |
| Status | Recruiting |
| Started | July 17, 2024 |
| Main results expected | December 31, 2026 |
| Study ends | September 30, 2027 |
| Registry record updated | June 30, 2026 |
| Trial ID | NCT06643065 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women undergoing assisted reproductive technology (ART) with the transfer of a euploid embryo.
✕Probably not a fit
Patients with significant uterine abnormalities or those who have recently taken antibiotics may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the relationship between the vaginal microbiome and clinical pregnancy outcomes in women undergoing euploid embryo transfers. By analyzing the presence of specific vaginal bacteria, the study seeks to determine if an imbalance in these microorganisms correlates with pregnancy failures. The findings could lead to recommendations for routine microbiome testing in fertility treatments, allowing for potential interventions to restore a healthy vaginal environment. The study is conducted across multiple centers to gather a diverse patient population.
Why it matters
Potential benefit: If successful, this study could lead to improved pregnancy outcomes for women undergoing fertility treatments by addressing vaginal microbiome imbalances.
How similar studies have gone: While the relationship between the vaginal microbiome and pregnancy outcomes is being explored, this study represents a novel approach in this specific context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ART patients undergoing the transfer of a euploid embryo Exclusion Criteria: * Patients with a body mass index (BMI) ≥35 * Patients with uncorrected uterine malformations * Patients with a unicornuate uterus * Patients with a bicornuate uterus * Patients with any type of submucosal myoma * Patients with an intramural myoma if ≥4 cm * Patients with severe adenomyosis (\>50% of the uterine corpus affected as defined by the MUSA criteria \[19\]) * Patients undergoing transfer of an embryo with a morphology score \<4BC (according to the Gardner \& Schoolcraft scoring system \[18\]) * Patients undergoing transfer of a day-7 embryo * Patients who took antibiotics in the month prior to the embryo transfer (excluding antibiotics given following oocyte retrieval)
Where it's running
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Ginefiv Barcelona
Barcelona, Spain Recruiting -
IVI Barcelona
Barcelona, Spain Recruiting -
IVI Bilbao
Bilbao, Spain Recruiting -
IVI Madrid
Madrid, Spain Recruiting -
Ginefiv Madrid
Madrid, Spain Recruiting -
IVI Málaga
Málaga, Spain Recruiting
Show 4 more locations
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Ginemed Sevilla
Seville, Spain Recruiting -
IVI Valencia
Valencia, Spain Recruiting -
IVI Vigo
Vigo, Spain Recruiting -
IVI Zaragoza
Zaragoza, Spain Recruiting
Study contacts
- Study coordinator: Courtney Povey
- Email: Courtney.Povey@junogenetics.com
- Phone: +34900828420
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This study is testing if taking synbiotics can help women at high risk for preterm birth have healthier pregnancies by improving their vaginal microbiome.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.