Comparing two surgical techniques for coronary artery bypass grafting

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of two surgical methods, RIMA-SVG and Ao-SVG, in patients undergoing coronary artery bypass grafting (CABG). A total of 300 patients will be randomly assigned to either the RIMA-SVG group, where saphenous vein grafts are connected to the right internal mammary artery, or the Ao-SVG group, where grafts are connected to the ascending aorta. The primary outcome is the patency of the grafts after one year, while secondary outcomes include complications such as mortality and major adverse cardiovascular events. Patients will be monitored for 12 months post-surgery to assess their clinical outcomes and graft health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients aged 18 to 80 years.
2. Scheduled for their first planned coronary artery bypass grafting (CABG) with at least two sequential saphenous vein grafts (SVGs).
3. Able and willing to provide written informed consent.

Exclusion Criteria:

1. Patients unable to provide written informed consent.
2. Patients requiring other cardiac surgeries (e.g. valve replacement, congenital heart defect surgery, or aortic dissection repair).
3. Patients with severe stenosis of the left or right subclavian artery.
4. Patients for whom aortic clamping is infeasible due to calcification of the ascending aorta.
5. Patients with bilateral SVG varicosities unsuitable for grafting.
6. Patients with active malignancy.
7. Patients with active bleeding or a history of bleeding tendency.
8. Patients with previous intracranial hemorrhage, ischemic stroke within 14 days preoperatively, or severe carotid artery stenosis.
9. Patients with severe hepatic dysfunction.
10. Patients requiring emergency surgery.

Where it's running

• the Second Hospital of Jilin University
  Changchun, Jilin, China Recruiting
• the Second Hospital of Jilin University
  Changchun, Jilin, China Recruiting

Study contacts

• Study coordinator: kexiang liu, Ph.D.
• Email: kxliu64@hotmail.com
• Phone: 17390920328

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.