Comparing two methods for treating wrist osteoarthritis
Official title: Norwegian Distal Ulna Resection vs. Replacement Study. A Prospective Randomized Multicenter Study
Run by Ostfold Hospital Trust · NCT04074863 · Data updated 2026-11-12
This study is testing whether a surgery that removes part of the wrist or a surgery that replaces it works better for people with painful wrist arthritis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 30 Years to 75 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Ostfold Hospital Trust Academic / other |
| Locations | 6 sites (Lillehammer, Oppland and 5 other locations) |
| Status | Recruiting |
| Started | September 16, 2020 |
| Main results expected | December 31, 2029 |
| Study ends | December 31, 2029 |
| Registry record updated | April 8, 2024 |
| Trial ID | NCT04074863 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals with painful osteoarthritis of the distal radioulnar joint who have stable joints.
✕Probably not a fit
Patients with active inflammatory diseases, significant instability in the DRUJ, or those who are considered 'low demand' may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to compare the effectiveness of the Darrach procedure, which involves resection of the ulnar head, with ulnar head replacement for treating osteoarthritis of the distal radioulnar joint (DRUJ). Participants will be individuals experiencing stable but painful DRUJ joints, and the study will be conducted as a prospective randomized multicenter trial across several hospitals in Norway. The goal is to determine which method provides better clinical outcomes and fewer complications. Informed consent will be obtained from all participants before enrollment.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment options for patients suffering from wrist osteoarthritis, enhancing their quality of life and functional capacity.
How similar studies have gone: While studies have shown good long-term results for both resection and replacement methods, this study is novel in directly comparing the two approaches.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * painful osteoarthritis distal radioulnar joint * stable DRUJ Exclusion Criteria: * activ inflammatory disease with significant destruction of the joint * "low demand" persons * significant instability i DRUJ * active infections, poor soft tissue conditions * accidental wound on the operated hand * general contraindications for surgery
Where it's running
-
Oslo University Hospital
Oslo, Norway Recruiting -
Østfold Hospital Trust
Moss, Østfold fylke, Norway Recruiting -
Innlandet Hospital Trust
Lillehammer, Oppland, Norway Not yet recruiting -
Haukeland University Hospital
Bergen, Norway Not yet recruiting -
University Hospital of North Norway
Tromsø, Norway Not yet recruiting -
University Hospital of St Olav
Trondheim, Norway Not yet recruiting
Study contacts
- Principal investigator: Istvan Zoltan Rigo, PhD — Ostfold Hospital Trust
- Study coordinator: Istvan Zoltan Rigo, PhD
- Email: istvan.zoltan.rigo@so-hf.no
- Phone: +47 69860000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Low-dose radiotherapy versus corticosteroid injection for hand and wrist osteoarthritis
This trial will test whether low-dose radiotherapy or a corticosteroid injection works better to reduce pain for people 50 and older with hand or wrist osteoarthritis.
-
Comparing wrist denervation and exercise for wrist osteoarthritis
This study is testing whether surgery to numb certain nerves in the wrist works better than a guided exercise program for people with wrist osteoarthritis.
-
Using machine learning to quickly detect deep vein thrombosis
This study is testing if a new machine learning tool can help doctors quickly rule out deep vein thrombosis in patients without needing an ultrasound every time.
-
Repairing the deltoid ligament in unstable ankle fractures
This study tests whether sewing the deep deltoid ligament in adults with unstable Weber B ankle fractures leads to better function and less long-term arthritis than fixing the outer ankle bone alone.
-
Surgery versus non-surgical care for mild to moderate bunions (hallux valgus)
This project will test whether surgery or non-surgical care (orthopedic aids and wider shoes) works better for adults with painful mild to moderate hallux valgus.
-
Testing a new guide for monitoring labor and childbirth in Norway
This study is testing a new guide for monitoring labor and childbirth to see if it can improve care and reduce unnecessary interventions for mothers and babies in Norway.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.