Clinical trial Recruiting at 1 site Interventional Ages 18 to 65

Comparing two hands-on neck therapies for cervicogenic headache

Official title: Comparison of the Eficacy of Mulligan Mobilization and Myofascial Release in Patients With Cervicogenic Headache

Run by Konya Beyhekim Training and Research Hospital · NCT07508410 · Data updated 2026-11-12

This will try Mulligan mobilization and myofascial release, each with a home exercise program, to see which helps adults aged 18–65 who have had cervicogenic (neck-origin) headache for at least three months.

Quick facts

Study typeInterventional
Ages18 Years to 65 Years
SexAll
Enrollment90 (estimated)
SponsorKonya Beyhekim Training and Research Hospital
Government
Locations1 site (Konya)
StatusRecruiting
StartedDecember 1, 2025
Main results expectedDecember 1, 2025
Study endsDecember 1, 2026
Registry record updatedApril 2, 2026
Trial IDNCT07508410 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–65 who meet diagnostic criteria for cervicogenic headache (for example unilateral pain, reduced neck range of motion, ipsilateral shoulder or arm symptoms) with symptoms for at least three months and who can attend in-person therapy sessions are appropriate candidates.

Probably not a fit

People with migraine or cluster headache, cervical radiculopathy, myelopathy, prior cervical spinal surgery, recent physical therapy (within 6 months), uncontrolled systemic or psychiatric illness, or who are pregnant are unlikely to benefit from these specific interventions in this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, randomized, hospital-based study that will enroll 90 adults (18–65 years) with cervicogenic headache lasting at least three months and randomly assign them to one of three groups. Group 1 will receive Mulligan mobilization plus a home exercise program, Group 2 will receive myofascial release plus the same home exercise program, and Group 3 will receive the home exercise program alone; treatment sessions occur three times per week for four weeks (12 sessions). Outcomes such as headache frequency and intensity, neck range of motion, and patient-reported disability will be measured at baseline, immediately after treatment, and one month after treatment. Sociodemographic and clinical data will be collected and the protocol follows ethical guidelines including informed consent and Helsinki principles.

Why it matters

Potential benefit: If successful, one or both manual therapies could reduce the frequency and severity of neck-related headaches and improve neck mobility and function.

How similar studies have gone: Previous research shows moderate benefit of manual and mobilization therapies for cervicogenic headache, but direct randomized head-to-head comparisons between Mulligan mobilization and myofascial release are limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion criteria:

* Individuals aged 18-65
* Having experienced neck or headache for 3 months
* Meeting the diagnostic criteria for cervicogenic headache;

  * Unilateral pain
  * Reduced range of motion in the neck
  * Ipsilateral shoulder discomfort
  * Ipsilateral arm discomfort
  * Pain that worsens with different neck movements and is painful on palpation

Exclusion criteria:

* Migraine
* Cluster headache
* Cervical radiculopathy
* Entrapment neuropathy
* Myelopathy
* Rheumatoid arthritis
* Undergoing cervical spinal surgery
* Pregnant women
* Those who received physical therapy within 6 months
* Those with a history of major psychiatric illness
* Those with a history of uncontrolled systemic diseases (cardiovascular, pulmonary, hepatic, renal, hematological)
* Those with a history of uncontrolled systemic endocrine diseases (dm, hyperthyroidism)

Where it's running

  • Konya Beyhekim Eğitim ve Araştırma Hastanesi
    Konya, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.