Comparing two hands-on neck therapies for cervicogenic headache
Official title: Comparison of the Eficacy of Mulligan Mobilization and Myofascial Release in Patients With Cervicogenic Headache
Run by Konya Beyhekim Training and Research Hospital · NCT07508410 · Data updated 2026-11-12
This will try Mulligan mobilization and myofascial release, each with a home exercise program, to see which helps adults aged 18–65 who have had cervicogenic (neck-origin) headache for at least three months.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | Konya Beyhekim Training and Research Hospital Government |
| Locations | 1 site (Konya) |
| Status | Recruiting |
| Started | December 1, 2025 |
| Main results expected | December 1, 2025 |
| Study ends | December 1, 2026 |
| Registry record updated | April 2, 2026 |
| Trial ID | NCT07508410 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 who meet diagnostic criteria for cervicogenic headache (for example unilateral pain, reduced neck range of motion, ipsilateral shoulder or arm symptoms) with symptoms for at least three months and who can attend in-person therapy sessions are appropriate candidates.
✕Probably not a fit
People with migraine or cluster headache, cervical radiculopathy, myelopathy, prior cervical spinal surgery, recent physical therapy (within 6 months), uncontrolled systemic or psychiatric illness, or who are pregnant are unlikely to benefit from these specific interventions in this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, randomized, hospital-based study that will enroll 90 adults (18–65 years) with cervicogenic headache lasting at least three months and randomly assign them to one of three groups. Group 1 will receive Mulligan mobilization plus a home exercise program, Group 2 will receive myofascial release plus the same home exercise program, and Group 3 will receive the home exercise program alone; treatment sessions occur three times per week for four weeks (12 sessions). Outcomes such as headache frequency and intensity, neck range of motion, and patient-reported disability will be measured at baseline, immediately after treatment, and one month after treatment. Sociodemographic and clinical data will be collected and the protocol follows ethical guidelines including informed consent and Helsinki principles.
Why it matters
Potential benefit: If successful, one or both manual therapies could reduce the frequency and severity of neck-related headaches and improve neck mobility and function.
How similar studies have gone: Previous research shows moderate benefit of manual and mobilization therapies for cervicogenic headache, but direct randomized head-to-head comparisons between Mulligan mobilization and myofascial release are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * Individuals aged 18-65 * Having experienced neck or headache for 3 months * Meeting the diagnostic criteria for cervicogenic headache; * Unilateral pain * Reduced range of motion in the neck * Ipsilateral shoulder discomfort * Ipsilateral arm discomfort * Pain that worsens with different neck movements and is painful on palpation Exclusion criteria: * Migraine * Cluster headache * Cervical radiculopathy * Entrapment neuropathy * Myelopathy * Rheumatoid arthritis * Undergoing cervical spinal surgery * Pregnant women * Those who received physical therapy within 6 months * Those with a history of major psychiatric illness * Those with a history of uncontrolled systemic diseases (cardiovascular, pulmonary, hepatic, renal, hematological) * Those with a history of uncontrolled systemic endocrine diseases (dm, hyperthyroidism)
Where it's running
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Konya Beyhekim Eğitim ve Araştırma Hastanesi
Konya, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Burcu Vural
- Email: burcuvural97@gmail.com
- Phone: +905389507278
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Post Isometric Relaxation vs Reciprocal Inhibition for Cervicogenic Headache
This study tests whether two gentle neck muscle techniques, post isometric relaxation and reciprocal inhibition, help people with cervicogenic headache more than a standard physical therapy routine.
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Kaltenborn vs Maitland Mobilization for Cervicogenic Headache
This trial tests whether Kaltenborn mobilization helps people with cervicogenic headache more than Maitland mobilization.
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Physical profile of cervicogenic headache vs neck pain and healthy people
This observational study tests whether posture, grip strength, muscle stiffness, elasticity, and pressure sensitivity differ among people with cervicogenic headache, chronic neck pain, and healthy controls.
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This will test whether osteopathic manipulative treatment or standard physiotherapy reduces dizziness, headaches, and neck pain better in adults with cervicocranial dysfunction.
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Third occipital nerve pulsed radiofrequency for cervicogenic headache
This trial will test whether ultrasound-guided pulsed radiofrequency of the third occipital nerve reduces pain in adults with cervicogenic headache who responded to a diagnostic nerve block.
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Steroid injection into neck muscle trigger points versus C2 dorsal root ganglion (nerve) block for chronic cervicogenic headache
This trial will test whether steroid injections into neck myofascial trigger points work as well as C2 dorsal root ganglion (nerve) blocks to reduce pain in adults with chronic cervicogenic headache.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.