Comparing two breathing support methods for preterm newborns with breathing difficulties

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the safety and efficacy of Continuous Positive Airway Pressure (CPAP) versus Non-Invasive Positive Pressure Ventilation (NIPPV) in preterm newborns suffering from Respiratory Distress Syndrome (RDS). The primary objective is to determine which method has a lower treatment failure rate, while secondary objectives include assessing mortality rates, intubation rates, and various complication rates associated with each method. The study will also analyze performance across different gestational age groups to understand the best approach for varying levels of prematurity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. gestational age (GA) between 22+0 and 34+6 weeks (estimated on the postmenstrual date and early gestation ultrasonographic findings).
2. Need of respiratory support (deemed by a clinician).

Exclusion Criteria:

1. Major congenital anomalies
2. Cardiovascular instability
3. Consent refused or not provided

Where it's running

• Vilnius University Santaros Klinikos
  Vilnius, Vilnius County, Lithuania Recruiting

Study contacts

• Study coordinator: Arunas Liubsys, Associate Professor
• Email: arunas.liubsys@santa.lt
• Phone: +370 6 872 2520

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Early prediction of lung injury in very preterm infants using EIT and lung ultrasound

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• Investigating Biomarkers in Acute Respiratory Distress Syndrome

  This study is trying to see if certain markers in the blood can help us understand how Acute Respiratory Distress Syndrome affects the lungs and how severe the condition is in patients.

  Recruiting University of Padova · Padova, PD · NCT06774534

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.