Comparing two antibiotics for treating Staphylococcus aureus bloodstream infections

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to determine whether benzylpenicillin is a more effective treatment than cloxacillin for patients with penicillin-susceptible Staphylococcus aureus bacteraemia. Adult patients over 18 years old diagnosed with this condition will be randomly assigned to receive either benzylpenicillin or cloxacillin after their blood cultures confirm the presence of the bacteria. The study will monitor treatment outcomes, including adverse events and effectiveness, over a specified duration based on the type of infection. The trial is designed to provide insights into optimizing antibiotic therapy for this serious infection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Aged ≥18 with penicillin susceptible S. aureus bacteraemia (PSSA), and able to provide written informed consent.

Exclusion Criteria:

* allergy to penicillin,
* inability to give informed consent,
* concomitant growth of other clinically significant bacteria in blood cultures
* neutropenia

  -≥ 96h with prior antibiotics
* When the per oral follow up medication can not be flukloxacillin or penicillinV/Amoxicillin (ie prosthetic joint infection)
* Patients in terminal palliation, where death is expected within 7 days.
* Where the treating physician believes cloxacillin is not a first-line treatment.

Where it's running

• Skånes universitetssjukhus, Region Skåne
  Lund, Sweden Recruiting

Study contacts

• Principal investigator: Malin Hagstrand Aldman, PhD, MD — Lund University
• Study coordinator: Malin Hagstrand Aldman, PhD
• Email: malin.hagstrand-aldman@skane.se
• Phone: +46768766308

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.