Comparing tibolone and E2V/MPA for menopausal symptoms
Official title: The Impact of Different Hormone Therapy Regimens on Overactive Bladder Symptoms, Sexual Function, Depressive Symptoms, Autonomic Function, and Arterial Stiffness
Run by Far Eastern Memorial Hospital · NCT05280028 · Data updated 2026-11-12
This study is testing whether two different hormone treatments, tibolone and a combination of estradiol valerate and medroxyprogesterone acetate, can help women with menopausal symptoms feel better.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years and up |
| Sex | Women only |
| Enrollment | 100 (estimated) |
| Sponsor | Far Eastern Memorial Hospital Academic / other |
| Locations | 1 site (Banqiao District, New Taipei) |
| Status | Recruiting |
| Started | February 7, 2022 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | June 17, 2024 |
| Trial ID | NCT05280028 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women over 20 years old with menopausal symptoms who have an intact uterus and no history of breast or other cancers.
✕Probably not a fit
Patients with a history of breast or other cancers or vascular-blocking diseases such as stroke may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effects of two hormone therapies, tibolone and estradiol valerate combined with medroxyprogesterone acetate (E2V/MPA), on various menopausal symptoms including overactive bladder, sexual function, heart rate variability, arterial stiffness, atherosclerosis, sleep quality, and depressive symptoms. It will involve female patients with intact uteri who are experiencing menopausal symptoms and will utilize a prospective, open-label design. Participants will complete several validated questionnaires to assess their symptoms and overall health outcomes.
Why it matters
Potential benefit: If successful, this study could help identify the most effective hormone therapy for alleviating menopausal symptoms in women.
How similar studies have gone: While there is limited literature on tibolone's effects, this study aims to fill a gap in comparative research, suggesting a novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>20 years old female * Menopausal symptoms, still have a uterus, and no breast or other cancers, and no vascular-blocking disease such as stroke. Exclusion Criteria: * Nil.
Where it's running
-
Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital
Banqiao District, New Taipei, Taiwan Recruiting
Study contacts
- Principal investigator: Sheng-Mou Hsiao, MD — Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital
- Study coordinator: Sheng-Mou Hsiao, MD
- Email: smhsiao2@gmail.com
- Phone: +8868966700
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.