Clinical trial Recruiting at 1 site Observational Ages 20 and up Women only

Comparing tibolone and E2V/MPA for menopausal symptoms

Official title: The Impact of Different Hormone Therapy Regimens on Overactive Bladder Symptoms, Sexual Function, Depressive Symptoms, Autonomic Function, and Arterial Stiffness

Run by Far Eastern Memorial Hospital · NCT05280028 · Data updated 2026-11-12

This study is testing whether two different hormone treatments, tibolone and a combination of estradiol valerate and medroxyprogesterone acetate, can help women with menopausal symptoms feel better.

Quick facts

Study typeObservational
Ages20 Years and up
SexWomen only
Enrollment100 (estimated)
SponsorFar Eastern Memorial Hospital
Academic / other
Locations1 site (Banqiao District, New Taipei)
StatusRecruiting
StartedFebruary 7, 2022
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedJune 17, 2024
Trial IDNCT05280028 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are women over 20 years old with menopausal symptoms who have an intact uterus and no history of breast or other cancers.

Probably not a fit

Patients with a history of breast or other cancers or vascular-blocking diseases such as stroke may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effects of two hormone therapies, tibolone and estradiol valerate combined with medroxyprogesterone acetate (E2V/MPA), on various menopausal symptoms including overactive bladder, sexual function, heart rate variability, arterial stiffness, atherosclerosis, sleep quality, and depressive symptoms. It will involve female patients with intact uteri who are experiencing menopausal symptoms and will utilize a prospective, open-label design. Participants will complete several validated questionnaires to assess their symptoms and overall health outcomes.

Why it matters

Potential benefit: If successful, this study could help identify the most effective hormone therapy for alleviating menopausal symptoms in women.

How similar studies have gone: While there is limited literature on tibolone's effects, this study aims to fill a gap in comparative research, suggesting a novel approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* \>20 years old female
* Menopausal symptoms, still have a uterus, and no breast or other cancers, and no vascular-blocking disease such as stroke.

Exclusion Criteria:

* Nil.

Where it's running

  • Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital
    Banqiao District, New Taipei, Taiwan
    Recruiting

Study contacts

  • Principal investigator: Sheng-Mou Hsiao, MD — Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital
  • Study coordinator: Sheng-Mou Hsiao, MD
  • Email: smhsiao2@gmail.com
  • Phone: +8868966700

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.