Using autologous PRP infusion to restore ovarian function in patients with premature ovarian insufficiency

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of autologous platelet-rich plasma (PRP) infusion in restoring ovarian function and promoting folliculogenesis in patients with premature ovarian insufficiency (POI). The study employs a triple-blind randomized controlled trial design, where participants receive either the PRP treatment or a placebo. PRP is derived from the patient's own blood and contains growth factors that may stimulate tissue growth and repair. The trial aims to assess the impact of this treatment on hormonal profiles and ovarian functionality in affected individuals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \< 40 years, presenting with amenorrhea or menstrual cycle irregularities for at least four months, and elevated FSH levels \>25 IU/L recorded on two occasions \>4 weeks apart
* Normal Karyotype: 46, XX
* Discontinuation of any complementary/adjuvant treatment including hormone replacement, acupuncture, and botanotherapy, for at least three months prior to recruitment.
* Willing to comply with study requirements

Exclusion Criteria:

* Any pathological disorder related to reproductive system anatomy
* AMH \> 8 pmol/L
* Endometriosis
* Adenomyosis
* Fibroids and adhesions
* Infections in reproductive system
* Current or previous diagnosis of cancer in reproductive system
* History of familiar cancer in reproductive system
* Severe male factor infertility
* Prior referral for PGT
* Ovarian inaccessibility
* Endocrinological disorders (Hypothalamus-Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)
* BMI\>30 kg/m2 or BMI\<18.5 kg/m2
* Systematic autoimmune disorders

Where it's running

• Genesis AC
  Athens, Greece Recruiting

Study contacts

• Study coordinator: Mara Simopoulou, PhD
• Email: marasimopoulou@hotmail.com
• Phone: +306979234100

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.