Maternal Methyl-Nutrient Status and Infant Neurodevelopment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective cohort follows pregnant women and their children to understand how maternal methyl-nutrient status links to infant neurodevelopment. It collects dietary data, blood and stool samples, and analyzes biomarkers and genetics related to one-carbon metabolism and gut microbiota. Infant outcomes include birth measurements and neurodevelopmental assessments at 6 months, 1 year, and 2 years. The study is conducted at Far Eastern Memorial Hospital and includes collaboration with Fu Jen Catholic University. It aims to clarify mechanistic pathways and identify potential associations across gestational stages.

Why it matters

Who can join: the full rules

Inclusion Criteria for Pregnant Women

* Aged 20-45 years
* Singleton pregnancy
* Receiving routine prenatal care at the study site and planning to deliver at Far Eastern Memorial Hospital

Exclusion Criteria for Pregnant Women

* Diagnosed with major chronic diseases, including renal disease (defined as chronic kidney disease stage 3 or above or history of renal transplantation), liver disease (defined as liver cirrhosis or history of liver transplantation), or malignancy
* Alcohol consumption during pregnancy
* Diagnosed with eating disorders or psychiatric conditions that may impair the assessment of nutritional status

Inclusion Criteria for Newborns

● Newborns delivered by mothers who participate in this study

Exclusion Criteria for Newborns

* Diagnosed with congenital anomalies, epilepsy, or severe brain injury
* Inability to complete neurodevelopmental assessments at 6 months, 1 year, and 2 years of age at the study site
* Infants whose mothers are diagnosed with eating disorders or psychiatric conditions that may impair the assessment of nutritional status

Where it's running

• Far Eastern Memorial Hospital
  New Taipei City, Taiwan Recruiting
• Far Eastern Memorial Hospital
  New Taipei City, Taiwan Not yet recruiting

Study contacts

• Study coordinator: Chi Man Kuok
• Email: carmentoe@hotmail.com
• Phone: (+886) 952289592

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.