Comparing patients with and without endocarditis undergoing valve surgery
The ENDOCARDITIS AUMC Data Collection : a Matched Cohort Study on Perioperative Coagulation in Conservatively and Surgically Treated Patients With Valvular Dysfunction, With and Without Infective Endocarditis
This study looks at how patients with and without endocarditis do during heart valve surgery to see if their treatment and recovery needs are different.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Academic / other |
| Locations | 1 site (Amsterdam, North Holland) |
| Trial ID | NCT05139589 on ClinicalTrials.gov |
What this trial studies
This observational study aims to compare patients with infective endocarditis to those without, who are undergoing cardiothoracic valve surgery. The investigators will evaluate various factors such as perioperative coagulation abnormalities, transfusion needs, and complications like thromboembolic events and mortality rates. By analyzing these differences, the study seeks to optimize perioperative care for high-risk patients with endocarditis. The research will also consider the impact of the specific pathogens causing endocarditis on patient outcomes.
Who should consider this trial
Good fit: Ideal candidates include patients over 18 years old with infective endocarditis scheduled for cardiac valve surgery.
Not a fit: Patients with a previous history of coagulation disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved perioperative care and outcomes for patients with endocarditis undergoing valve surgery.
How similar studies have performed: Similar studies have shown success in optimizing care for high-risk surgical patients, making this approach promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients \> 18 years * Dutch or English speaking * All patients with infective endocarditis admitted to Amsterdam UMC in the study period * All patients with infective endocarditis scheduled for cardiac valve surgery compared to a matched cohort of patients scheduled for similar surgery due to non-infectious indication in Amsterdam UMC in the same period Exclusion Criteria: * Previous history of coagulation disorders
Where this trial is running
Amsterdam, North Holland
- Academic Medical Center — Amsterdam, North Holland, Netherlands (Recruiting)
Study contacts
- Principal investigator: Markus W Hollmann, MD,PhD,PhD — Amsterdam Academic Medical Center
- Study coordinator: Jennifer S Breel, MPA,MSc
- Email: j.s.breel@amsterdamumc.nl
- Phone: +31610019257
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.