Comparing neuromonitoring techniques during scarless thyroid surgery
Official title: Comparison of Intr-operative Neuromonitoring Technique in Trans-oral Endoscopic Thyroidectomy Vestibular Approach
Run by China Medical University Hospital · NCT06801444 · Data updated 2026-11-12
This study is testing two different ways to monitor nerve function during a type of thyroid surgery to see which one better helps prevent nerve damage.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 304 (estimated) |
| Sponsor | China Medical University Hospital Academic / other |
| Locations | 1 site (Taichung) |
| Status | Recruiting |
| Started | March 29, 2023 |
| Main results expected | December 11, 2025 |
| Study ends | December 11, 2025 |
| Registry record updated | January 30, 2025 |
| Trial ID | NCT06801444 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with benign thyroid nodules or early-stage papillary thyroid carcinoma who meet specific size criteria.
✕Probably not a fit
Patients with a history of thyroid surgery, neck radiotherapy, or recurrent laryngeal nerve paralysis may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study evaluates the effectiveness of different intraoperative neuromonitoring techniques used during transoral endoscopic thyroidectomy vestibular approach (TOETVA) to prevent recurrent laryngeal nerve injury. It compares intermittent intraoperative neuromonitoring (I-IONM) with a novel continuous intraoperative neuromonitoring (C-IONM) technique developed at the China Medical University Hospital. The study involves a retrospective analysis of 304 patients who underwent TOETVA, categorizing them based on the neuromonitoring technique used. The goal is to assess the impact of these techniques on patient outcomes, particularly nerve function preservation.
Why it matters
Potential benefit: If successful, this study could lead to improved nerve function preservation during thyroid surgeries, reducing the risk of complications for patients.
How similar studies have gone: While the use of continuous intraoperative neuromonitoring is relatively novel, similar approaches have shown promise in other surgical contexts, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Benign solitary or multiple thyroid nodules, follicular lesions (the largest diameter \<6.0 cm), and early papillary thyroid carcinoma (\<1 cm in diameter, without cervical lymphadenopathy) Exclusion Criteria: History of thyroid surgery, neck radiotherapy, and recurrent laryngeal nerve paralysis; intraoperative conversion to conventional thyroidectomy.
Where it's running
-
China Medical University Hospital
Taichung, Taiwan Recruiting
Study contacts
- Study coordinator: Yih-Huei Uen, MD
- Email: d84306@yahoo.com.tw
- Phone: 886-4-37061668
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Opioid-Free vs Opioid-Based Anesthesia for Thyroid Surgery
This study tests whether a non-opioid anesthesia approach can match or improve outcomes for adults undergoing thyroidectomy.
-
NIRAF-guided identification of parathyroids during thyroidectomy
A wearable near-infrared autofluorescence device is being tested to help surgeons find and protect the parathyroid glands during thyroid surgery in adults.
-
Cold (non-thermal) plasma to improve healing and reduce complications after thyroid removal
This will test whether applying helium-based non-thermal (cold) plasma during total thyroidectomy helps wounds heal faster and reduces pain, inflammation, and infections in adults having their thyroid removed.
-
Transoral (TOETVA) versus standard front‑neck (anterior cervical) thyroid surgery for lobectomy or thyroidectomy
This trial will test whether the transoral (TOETVA) scar‑hiding approach works as well and is as safe as the standard front‑neck (anterior cervical) operation for adults needing lobectomy or thyroidectomy.
-
Water-based burpee exercises to improve functional capacity in postmenopausal women after thyroidectomy
This program will test whether doing burpee exercises in a pool helps improve strength and day-to-day functioning in postmenopausal women who have had a thyroidectomy.
-
Thyroid removal for Graves' disease or amiodarone-induced thyrotoxicosis
The study will try to see if adults having their thyroid removed for Graves' disease or amiodarone-induced thyrotoxicosis have different complication rates depending on how active their thyroid is before or during surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.