Transoral (TOETVA) versus standard front‑neck (anterior cervical) thyroid surgery for lobectomy or thyroidectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional comparison enrolls adults 18–65 who need a lobectomy or thyroidectomy and have a thyroid volume under 60 mL and nodules under 4 cm. Participants receive either transoral endoscopic thyroidectomy by vestibular approach (TOETVA) or conventional anterior cervical (AC) thyroidectomy, with perioperative care and planned follow‑up. Outcomes include surgical efficacy, complication rates, cosmetic results, and recovery metrics such as pain and return to normal activities. The protocol excludes patients with prior cervical surgery, identified malignant lymph nodes, associated parathyroid procedures, or unstable severe illness, and is run at several French university and regional hospitals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with a surgical indication for lobectomy or thyroidectomy
* Estimated thyroid volume measured by ultrasonography of less than 60 mL
* Nodules suspected to be malignant measuring less than 4 cm
* Patient aged between 18 and 65 years old
* Patient who has benefited from an endocrinological evaluation, with a favorable opinion for TOETVA or AC Patient who understands and accepts the need for follow-up
* Patient who agrees to be included in the study and who signs the informed consent form
* Patient affiliated to a healthcare insurance plan

Exclusion Criteria:

* Patients refusing an alternative to AC or refusing AC
* History of cervical surgery
* Associated parathyroid surgery
* Identification of malignant lymph nodes
* Presence of a severe and evolutive life threatening pathology
* Patients with unstable psychiatric disorder, under supervision or guardianship
* Patient who does not understand French/ is unable to give consent
* Patient not affiliated to a French or European healthcare insurance
* Patient who has already been included in a trial which has a conflict of interests with the present study
* Pregnant or breast-feeding patient
* Patient incarcerated

Where it's running

• CHU de Lille, Hôpital Huriez
  Lille, France Recruiting
• AP-HP - Hôpital Avicennes
  Bobigny, France Not yet recruiting
• Hôpital Franco-Britannique
  Levallois-Perret, France Not yet recruiting
• CHU Dupuytren
  Limoges, France Not yet recruiting
• CHU de Nantes - Hôtel Dieu
  Nantes, France Not yet recruiting
• AP-HP - Hôpital Cochin
  Paris, France Not yet recruiting

Study contacts

• Study coordinator: Robert Caiazzo, Prof.
• Email: robert.caiazzo@chu-lille.fr
• Phone: +33 (0)3 20 44 55 15

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.