Comparing different therapies for Helicobacter pylori eradication

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial aims to compare the effectiveness and safety of three different treatment regimens for Helicobacter pylori infection: a 14-day bismuth-amoxicillin-vonoprazan triple therapy, a 14-day vonoprazan dual therapy, and a 14-day rabeprazole triple therapy. The study will recruit 780 adult patients from ten medical centers in Taiwan and will utilize a randomized, open-label design. Participants will be monitored for drug adherence and adverse events, with H. pylori status assessed through a breath test six weeks post-treatment. The trial will also explore the impact of antibiotic resistance and specific genetic factors on treatment efficacy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

(1) At least 18 years old. (2) Subjects infected with Helicobacter pylori.

Exclusion Criteria:

1. Those who have ever received Helicobacter pylori sterilization treatment.
2. Those who are allergic to the drugs used in this research.
3. Those who have had stomach surgery.
4. Those with severe liver cirrhosis or uremia or malignant tumors.
5. Women who are pregnant or breastfeeding.

Where it's running

• Kaohsiung Medical University Hospital
  Kaohsiung City, Taiwan Recruiting

Study contacts

• Study coordinator: Deng-Chyang Wu, MD, PHD
• Email: dechwu@yahoo.com
• Phone: 88673121101

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.