Comparing dexmedetomidine and lidocaine for managing pain after mastectomy
Intraoperative Intravenous Infusion of Dexmedetomidine Versus Lidocaine in Management of Acute Postoperative Pain After Modified Radical Mastectomy: A Randomized Trial
This study tests whether the medications dexmedetomidine or lidocaine can help reduce pain better after mastectomy surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | Female |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06974656 on ClinicalTrials.gov |
What this trial studies
This study compares the effectiveness of intravenous dexmedetomidine and lidocaine in managing acute postoperative pain following modified radical mastectomy. It addresses the challenge of inadequate pain control that can hinder recovery and lead to chronic pain. By evaluating these two adjuvants, the study aims to identify which provides better pain relief and improves patient outcomes after surgery.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 scheduled for modified radical mastectomy with an ASA physical status of II and a BMI between 18.5 and 35 kg/m2.
Not a fit: Patients with contraindications to local anesthetics, significant comorbidities, or those currently using certain medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing mastectomy, enhancing their recovery experience.
How similar studies have performed: Previous studies have shown promise in using dexmedetomidine and lidocaine for postoperative pain management, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 18 to 65 years. * American Society of Anesthesiology (ASA) physical status II. * Body mass index (BMI) 18.5-35 kg/m2. * Scheduled for modified radical mastectomy. Exclusion Criteria: * Patient's refusal. * Contraindication to the use of local anesthetics. * Cardiovascular disease. * Significant renal/hepatic impairment * Insulin-dependent diabetes mellitus. * Central nervous system or psychiatric disease. * Use of opioids/steroids/clonidine/other α2 agonist/analgesics or any drugs acting on the central nervous system during the previous 2 weeks. * Drug/alcohol abuse. * Inability to comprehend the pain assessment scale.
Where this trial is running
Cairo
- Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Mohamed E Abdel Fattah, MD
- Email: mohamed-elsaid@cu.edu.eg
- Phone: 00201284475792
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.