Comparing citrate and acetate dialysate for better hemodynamic stability during hemodialysis in ICU patients
Official title: Improved Hemodynamic Tolerance of Intermittent Hemodialysis Sessions in Intensive Care Unite (ICU) Using Citrate- vs Acetate-based Dialysate
Run by Centre Hospitalier de Bethune · NCT05936710 · Data updated 2026-11-12
This study is testing whether using citrate instead of acetate in dialysis can help ICU patients feel more stable and avoid low blood pressure during their treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 48 (estimated) |
| Sponsor | Centre Hospitalier de Bethune Research network |
| Locations | 5 sites (Béthune and 4 other locations) |
| Status | Recruiting |
| Started | December 7, 2023 |
| Main results expected | July 2027 |
| Study ends | July 2027 |
| Registry record updated | May 8, 2026 |
| Trial ID | NCT05936710 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who are hospitalized in an intensive care unit with acute renal failure and at risk of per dialytic hypotension.
✕Probably not a fit
Patients with chronic renal insufficiency, unstable hemodynamic states, or those who are pregnant or breastfeeding may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the hemodynamic tolerance and effectiveness of citrate-based dialysate compared to acetate-based dialysate during intermittent hemodialysis in patients hospitalized in intensive care units. It focuses on patients experiencing intradialytic hypotension, a common complication that can lead to increased morbidity and mortality. By using citrate-based dialysate, the study seeks to determine if it can provide better stability and outcomes for patients undergoing hemodialysis. The study will involve patients who meet specific criteria related to acute renal failure and risk of hypotension.
Why it matters
Potential benefit: If successful, this study could lead to improved hemodynamic stability during hemodialysis, reducing complications and enhancing patient outcomes.
How similar studies have gone: While the use of citrate-based dialysate is a newer approach, previous studies have indicated potential benefits, but this specific comparison is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient ≥ 18 years old * Patient hospitalized in an intensive care unit * Patient with acute renal failure defined by a KDIGO stage ≥ 1 and suspected non-obstructive * Patient at risk of per dialytic hypotension (capillary refill time ≥ 3 seconds and/or cardiovascular SOFA ≥ 1 and/or lactatemia \> 2mmol/L) * Indication for Extra Renal Replacement Therapy with IHD. Exclusion Criteria: * Pregnant or breastfeeding woman * Known chronic renal insufficiency of any stage * Cardio-renal and hepato renal syndrome * Unstable hemodynamic state: refractory shock * Patient included in another interventional study likely to modify the hemodynamic state * Patient deprived of liberty * Patient under guardianship or curatorship * Patient not affiliated to a social security system
Where it's running
-
Centre Hospitalier Béthune
Béthune, France Recruiting -
Chu
Caen, France Recruiting -
Centre Hospitalier Universitaire de Dijon
Dijon, France Recruiting -
CHRU Nancy
Nancy, France Recruiting -
CHU de ROUEN
Rouen, France Not yet recruiting
Study contacts
- Study coordinator: Martin GÉRARD
- Email: mgerard@ch-bethune.fr
- Phone: 03.21.64.44.44
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Preventing low blood pressure during ICU dialysis using a Hypotension Prediction Index
This trial tests whether using a Hypotension Prediction Index to guide care during prolonged dialysis can reduce episodes of low blood pressure in critically ill adults who have an arterial line.
-
Using IVC collapsibility and diameters to predict blood pressure drops during hemodialysis
This project tries to see whether measuring the inferior vena cava collapsibility index and diameters one hour into dialysis can predict blood pressure drops in adults on maintenance hemodialysis.
-
Carotid ultrasound to predict blood pressure drops during dialysis
We're testing whether carotid ultrasound measurements can help predict which adults on long-term hemodialysis will have drops in blood pressure during treatment.
-
Pleth Variability Index to predict low blood pressure during maintenance hemodialysis
This will test whether a simple pulse-oximeter reading (PVI) can help predict which adults on routine hemodialysis will develop low blood pressure so clinicians can act earlier.
-
Comparing lower and higher bicarbonate levels in dialysis patients
This study tests if using lower or higher levels of bicarbonate during dialysis can affect heart rhythms and other symptoms in adult patients.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.