Using IVC collapsibility and diameters to predict blood pressure drops during hemodialysis
The Predictive Value of the Inferior Vena Cava Collapsibility Index for Intradialytic Hypotension: A Prospective Multicenter Observational Stud
This project tries to see whether measuring the inferior vena cava collapsibility index and diameters one hour into dialysis can predict blood pressure drops in adults on maintenance hemodialysis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 188 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | First Affiliated Hospital of Wannan Medical College Academic / other |
| Locations | 1 site (Wuhu, Anhui) |
| Trial ID | NCT07033273 on ClinicalTrials.gov |
What this trial studies
This is a multicenter prospective observational study that records inferior vena cava (IVC) measurements once, at one hour after dialysis start, to see how well IVCCI, IVCmax, and IVCmin predict intradialytic hypotension. Ultrasound measurements will be collected at participating hospitals in Wuhu and linked to blood pressure readings and dialysis session data. Eligible participants are adults with end-stage renal disease on maintenance hemodialysis for at least three months, while patients with acute kidney injury, severe cardiac disease, hemodynamic instability, or barriers to ultrasound are excluded. The study uses noninvasive bedside ultrasonography and correlational analysis to determine whether a single-timepoint IVC metric can identify patients at higher risk of hypotension during dialysis.
Who should consider this trial
Good fit: Adults aged 18 years or older with end-stage renal disease receiving regular maintenance hemodialysis for at least three months who are hemodynamically stable and can undergo ultrasound are ideal candidates.
Not a fit: Patients with acute kidney injury, severe cardiac conditions (NYHA Class III–IV), those requiring vasopressor support, pregnant or breastfeeding women, or those unable to undergo ultrasound are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, this approach could provide a simple, noninvasive bedside tool to identify patients at higher risk of intradialytic hypotension so teams can adjust fluid removal or apply preventive measures.
How similar studies have performed: Prior small observational studies have suggested a relationship between IVC collapsibility/diameters and intravascular volume or hypotension risk, but results have been mixed and larger prospective validation is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 years or older. * Diagnosed with end-stage renal disease (ESRD). * Undergoing regular hemodialysis for at least three months. Exclusion Criteria: * Pregnant or breastfeeding women. * Hemodynamically unstable patients or those requiring vasopressor support. * Patients with severe cardiac conditions, including congestive heart failure -classified as NYHA Class III-IV or severe valvular disease. * Patients with known allergies to dialysis filters. * Dialysis sessions terminated for reasons unrelated to hypotension (e.g., technical issues, patient request). * Patients who withdraw informed consent during the study. * Use of antihypertensive medications during dialysis sessions. * Inability to undergo ultrasound assessment due to factors such as severe obesity or wounds obstructing access.
Where this trial is running
Wuhu, Anhui
- The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College) — Wuhu, Anhui, China (Recruiting)
Study contacts
- Study coordinator: Qiancheng Xu
- Email: qianchengxu@wnmc.edu.cn
- Phone: 86-18297529106
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.