Carotid ultrasound to predict blood pressure drops during dialysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter prospective observational study will enroll adults with end-stage renal disease receiving maintenance hemodialysis to measure carotid corrected flow time (FTc) and peak flow velocity variability (PFVV). Ultrasound assessments will be performed once at about one hour after dialysis initiation while blood pressure is continuously monitored during the session. The primary analysis will determine the sensitivity, specificity, and optimal cutoff points of FTc and PFVV for predicting intradialytic hypotension. Patients with major carotid stenosis, significant arrhythmias, hemodynamic instability, or inability to undergo ultrasound are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adults aged 18 to 80 years. Diagnosed with end-stage renal disease (ESRD). Undergoing maintenance hemodialysis for more than three months. Willing and able to provide informed consent and comply with study procedures.

Exclusion Criteria:

Patients with significant carotid artery stenosis due to heavy atherosclerotic plaque (defined as more than 70% stenosis confirmed by ultrasound or angiography).

Hemodynamically unstable patients or those requiring vasopressor support. Patients with significant arrhythmias (e.g., atrial fibrillation, ventricular tachycardia).

Dialysis sessions terminated for reasons unrelated to hypotension (e.g., technical issues, patient request).

Use of antihypertensive medications during dialysis sessions. Inability to undergo ultrasound assessment due to factors such as severe obesity or wounds obstructing access.

Patients who withdraw informed consent during the study.

Where it's running

• The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)
  Wuhu, Outside of the US, China Recruiting

Study contacts

• Study coordinator: Qiancheng Xu
• Email: qianchengxu@wnmc.edu.cn
• Phone: 86-18297529106

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.