Comparing aminophylline and furosemide combination to furosemide alone for diuresis in critically ill adults
Diuretic Efficacy of Aminophylline and Furosemide Combination vs Furosemide Alone in Critically Ill Adults
This study is testing if combining aminophylline with furosemide helps critically ill adults in the ICU produce more urine than just using furosemide alone.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Enrollment | 132 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Malaya Academic / other |
| Locations | 1 site (Kuala Lumpur) |
| Trial ID | NCT05933642 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of a combination of aminophylline and furosemide compared to furosemide alone in promoting diuresis in critically ill adults admitted to the ICU. Patients who are oliguria and require enhanced urine output will be randomly assigned to receive either the combination treatment or furosemide alone. Their hourly urine output will be closely monitored to assess the efficacy of the treatments. The study is designed to provide insights into improving diuretic strategies in critical care settings.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are admitted to the ICU and are experiencing oliguria.
Not a fit: Patients with known hypersensitivity to aminophylline or furosemide, or those with certain medical conditions such as tachyarrhythmias or peptic ulcer disease, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diuretic management for critically ill patients, potentially enhancing kidney function recovery.
How similar studies have performed: While this approach is being tested in this trial, similar studies have shown varying degrees of success with diuretic combinations in critical care settings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 years old and above who are admitted to the ICU of UMMC during the study period * Oliguric patients, with the need for improved diuresis at clinician discretion - defined as urine output \<0.5ml/kg/hour Exclusion Criteria: * Patient refusal for participation of study * Patients with known hypersensitivity reaction to aminophylline or furosemide * Patients with history of tachyarrhythmias, seizures, aspartate aminotransferase or alanine aminotransferase \> 3 times normal, or hypothyroidism. Patient with existing peptic ulcer disease or coagulopathy with INR \> 1.5
Where this trial is running
Kuala Lumpur
- University of Malaya — Kuala Lumpur, Malaysia (Recruiting)
Study contacts
- Principal investigator: Haw Shyan Ng — University of Malaya
- Study coordinator: Haw Shyan Ng
- Email: plue_chris@yahoo.co.uk
- Phone: +6 016 483 7722
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.