Combining dexmedetomidine and esketamine to improve sleep quality after mastectomy
Dexmedetomidine Combined With Esketamine Effects the Quality of Sleep
This study is testing if combining two medications, dexmedetomidine and esketamine, can help women sleep better after having breast surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 105 (estimated) |
| Ages | 25 Years to 65 Years |
| Sex | Female |
| Sponsor | Anqing Municipal Hospital Academic / other |
| Locations | 1 site (Anqing, Anhui) |
| Trial ID | NCT06414941 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of combining dexmedetomidine and esketamine on postoperative sleep quality in women undergoing elective modified radical mastectomy. A total of 105 participants will be randomly assigned to three groups, receiving different combinations of dexmedetomidine and esketamine before and during surgery. The aim is to determine if the co-administration of these medications can enhance sleep quality compared to dexmedetomidine alone. The study will measure sleep quality outcomes post-surgery to evaluate the effectiveness of the treatment.
Who should consider this trial
Good fit: Ideal candidates are women scheduled for elective modified radical mastectomy with ASA physical status I or II.
Not a fit: Patients with severe respiratory disease, renal or hepatic insufficiency, or a history of preoperative psychiatric conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve postoperative sleep quality for patients undergoing mastectomy.
How similar studies have performed: Previous studies have indicated that both dexmedetomidine and esketamine can improve sleep quality, suggesting potential success for this combined approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status Ⅰ- Ⅱ * Scheduled for elective modified radical mastectomy Exclusion Criteria: * Severe respiratory disease * Renal or hepatic insufficiency * History of preoperative psychiatric * Preoperative bradycardia * Preoperative atrioventricular block * Preoperative hypertension * BMI\>30
Where this trial is running
Anqing, Anhui
- Department of Anqing Hospital Anesthesiology — Anqing, Anhui, China (Recruiting)
Study contacts
- Study coordinator: Xu si qi, Doctor
- Email: errtg555@163.com
- Phone: 13865192106
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.